Department of Maternal, Child and Adolescent Health, School of Public Health, Anhui Medical University, Hefei, Anhui, China.
Department of Child and Adolescent Health, School of Public Health, Nantong University, Nantong, Jiangsu, China.
PLoS One. 2018 Mar 9;13(3):e0192901. doi: 10.1371/journal.pone.0192901. eCollection 2018.
Although numerous studies have described the relationship between HPA axis dysregulation and internalizing symptoms among adolescents, research using hair cortisol concentrations in pre- and young adolescent samples has not been reported. We investigated the association of self-reported internalizing symptoms with cortisol concertration in hair among pre- and young adolescents aged 10-12 years. Forty-six boys and 39 girls supplied a hair sample of at least 3 cm in length for an analysis of this period (3 months) cortisol excretion. Saliva cortisol reactivity to the Trier Social Stress Test for Children (TSST-C) also was assessed. The study found a positive association between ratings of depressive symptoms and cumulative levels of hair cortisol only in boys. Furthermore, higher ratings of anxiety symptoms were associated with lower hair cortisol concertration and lower saliva cortisol reactivity among girls. This study provides the first evidence for the notion that depressive symptoms in boys are associated with long-term cortisol concertration in hair, whereas anxiety symptoms in girls are associated with HPA-axis hypoactivity, when hair cortisol concentrations and saliva cortisol reactivity to acute stress are assessed concurrently.
尽管许多研究描述了 HPA 轴失调与青少年内化症状之间的关系，但使用毛发皮质醇浓度在青春期前和青少年早期样本中的研究尚未报道。我们研究了自我报告的内化症状与 10-12 岁青春期前和青少年时期的毛发皮质醇浓度之间的关系。46 名男孩和 39 名女孩提供了至少 3 厘米长的头发样本，用于分析这段时间（3 个月）的皮质醇排泄。唾液皮质醇对儿童特里尔社会应激测试（TSST-C）的反应也进行了评估。研究发现，抑郁症状评分与男孩毛发皮质醇的累积水平之间呈正相关。此外，女孩的焦虑症状评分较高与较低的毛发皮质醇浓度和较低的唾液皮质醇反应性相关。这项研究首次提供了这样一种观点的证据，即男孩的抑郁症状与毛发皮质醇的长期浓度有关，而女孩的焦虑症状与 HPA 轴功能低下有关，当同时评估毛发皮质醇浓度和急性应激时唾液皮质醇反应。
