Faculty of Kinesiology, University of Calgary, 2500 University Dr NW, Calgary, AB T2N 1N4, Canada.
Faculty of Nutrition, Pelotas Federal University, Rua: Gomes Carneiro 1, Centro, 96010-610 Pelotas, Brazil.
Vascul Pharmacol. 2018 Jul;106:67-73. doi: 10.1016/j.vph.2018.03.002. Epub 2018 Mar 6.
This study aimed to investigate whether the influence of CYP1A2 genotype in the blood pressure (BP) response to caffeine ingestion was affected by physical activity status and habitual caffeine consumption. Thirty-seven participants (19-50 years old) took place in the study and were categorized according to i) genotype: CYP1A2 (AA) "fast metabolizer", and CYP1A2 (AC) "slow metabolizer"; ii) physical activity level: sedentary (S) and physically active (A); and iii) caffeine consumption level: non-habitual caffeine consumer (NC) and habitual heavy caffeine consumer (C). All groups had BP assessed before (basal) and 1 hourh after (post) caffeine ingestion (6 mg·kg). It was observed that AC genotype individuals had increased basal-DBP and post-caffeine SBP when compared to AA individuals. Additionally, acute caffeine ingestion increased SBP only in the AC group. It was also found that physical activity only modulated the BP responses to acute caffeine ingestion in AC individuals. Furthermore, the results indicated that the habitual heavy caffeine consumers AC individuals had increased basal-DBP when compared to the AA ones. Our results suggest that the influence of CYP1A2 genotype in the basal and post-caffeine BP response to caffeine ingestion is modified by physical activity status and caffeine consumption level.
本研究旨在探究 CYP1A2 基因型对咖啡因摄入引起的血压（BP）反应的影响是否受身体活动状态和习惯性咖啡因摄入的影响。37 名参与者（19-50 岁）参与了研究，并根据以下因素进行了分类：i）基因型：CYP1A2（AA）“快速代谢型”和 CYP1A2（AC）“慢速代谢型”；ii）身体活动水平：久坐（S）和活跃（A）；iii）咖啡因摄入水平：非习惯性咖啡因消费者（NC）和习惯性大量咖啡因消费者（C）。所有组在摄入咖啡因前（基础）和摄入后 1 小时（后）均评估了 BP（6mg·kg）。结果显示，与 AA 个体相比，AC 基因型个体的基础舒张压和咖啡因后收缩压升高。此外，急性咖啡因摄入仅增加了 AC 组的收缩压。还发现，只有在 AC 个体中，身体活动才会调节急性咖啡因摄入对 BP 的反应。此外，结果表明，与 AA 个体相比，习惯性大量摄入咖啡因的 AC 个体的基础舒张压升高。我们的研究结果表明，CYP1A2 基因型对咖啡因摄入引起的基础和咖啡因后 BP 反应的影响受身体活动状态和咖啡因摄入水平的调节。
