Department of Neurology, Mayo Clinic, Phoenix, AZ, USA.
Lancet. 2018 Mar 31;391(10127):1315-1330. doi: 10.1016/S0140-6736(18)30478-1. Epub 2018 Mar 6.
Migraine is a chronic paroxysmal neurological disorder characterised by multiphase attacks of head pain and a myriad of neurological symptoms. The underlying genetic and biological underpinnings and neural networks involved are coming sharply into focus. This progress in the fundamental understanding of migraine has led to novel, mechanism-based and disease-specific therapeutics. In this Seminar, the clinical features and neurobiology of migraine are reviewed, evidence to support available treatment options is provided, and emerging drug, device, and biological therapies are discussed.
偏头痛是一种慢性阵发性神经系统疾病，其特征是反复发作的头痛和多种神经系统症状。其潜在的遗传和生物学基础以及涉及的神经网络正变得越来越清晰。偏头痛基础理解方面的这一进展导致了新型、基于机制和针对疾病的治疗方法。在本次研讨会中，回顾了偏头痛的临床特征和神经生物学，提供了支持现有治疗选择的证据，并讨论了新兴的药物、设备和生物疗法。
