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加拿大急诊科谵妄的发生率及其对住院时间的影响:一项前瞻性观察性多中心队列研究。

Incidence of delirium in the Canadian emergency department and its consequences on hospital length of stay: a prospective observational multicentre cohort study.

作者信息

Émond Marcel, Boucher Valérie, Carmichael Pierre-Hugues, Voyer Philippe, Pelletier Mathieu, Gouin Émilie, Daoust Raoul, Berthelot Simon, Lamontagne Marie-Eve, Morin Michèle, Lemire Stéphane, Minh Vu Thien Tuong, Nadeau Alexandra, Rheault Marcel, Juneau Lucille, Le Sage Natalie, Lee Jacques

机构信息

Axe Santé des populations et pratiques optimales en santé, Centre de recherche du CHU de Québec-Université Laval, Québec, Canada.

Département de médecine d'urgence, CHU de Québec-Université Laval, Québec, Canada.

出版信息

BMJ Open. 2018 Mar 8;8(3):e018190. doi: 10.1136/bmjopen-2017-018190.

Abstract

OBJECTIVE

We aim to determine the incidence of delirium and describe its impacts on hospital length of stay (LOS) among non-delirious community-dwelling older adults with an 8-hour exposure to the emergency department (ED) environment.

DESIGN

This is a prospective observational multicentre cohort study (March-July 2015). Patients were assessed two times per day during their entire ED stay and up to 24 hours on hospital ward.

SETTING

The study took place in four Canadian EDs.

PARTICIPANTS

338 included patients: (1) aged ≥65 years; (2) who had an ED stay ≥8 hours; (3) were admitted to hospital ward and (4) were independent/semi-independent.

MAIN OUTCOMES AND MEASURES

The primary outcomes of this study were incident delirium in the ED or within 24 hours of ward admission and ED and hospital LOS. Functional and cognitive status were assessed using validated Older Americans Resources and Services and the modified Telephone Interview for Cognitive Status tools. The Confusion Assessment Method was used to detect incident delirium. Univariate and multivariate analyses were conducted to evaluate outcomes.

RESULTS

Mean age was 76.8 (±8.1), 17.7% were aged >85 years old and 48.8% were men. The mean incidence of delirium was 12.1% (n=41). Median IQR ED LOS was 32.4 (24.5-47.9) hours and hospital LOS was 146.6 (75.2-267.8) hours. Adjusted mean hospital LOS was increased by 105.4 hours (4.4 days) (95% CI 25.1 to 162.0, P<0.001) for patients who developed an episode of delirium compared with non-delirious patient.

CONCLUSIONS

An incident delirium was observed in one of eight independent/semi-independent older adults after an 8-hour ED exposure. An episode of delirium increases hospital LOS by 4 days and therefore has important implications for patients and could contribute to ED overcrowding through a deleterious feedback loop.

摘要

目的

我们旨在确定谵妄的发生率,并描述其对在急诊科(ED)环境中暴露8小时的非谵妄社区居住老年人住院时间(LOS)的影响。

设计

这是一项前瞻性观察性多中心队列研究(2015年3月至7月)。患者在整个急诊科停留期间每天评估两次,在医院病房最多评估24小时。

地点

该研究在四个加拿大急诊科进行。

参与者

338名纳入患者:(1)年龄≥65岁;(2)急诊科停留时间≥8小时;(3)入住医院病房;(4)独立/半独立。

主要结局和测量指标

本研究的主要结局是急诊科或病房入院后24小时内发生的谵妄以及急诊科和住院时间。使用经过验证的美国老年人资源与服务量表和改良的认知状态电话访谈工具评估功能和认知状态。使用谵妄评估方法检测新发谵妄。进行单变量和多变量分析以评估结局指标。

结果

平均年龄为76.8(±8.1)岁,17.7%的患者年龄>85岁,48.8%为男性。谵妄的平均发生率为12.1%(n = 41)。急诊科住院时间的中位数IQR为32.4(24.5 - 47.9)小时,住院时间为146.6(75.2 - 267.8)小时。与未发生谵妄的患者相比,发生谵妄的患者调整后的平均住院时间增加了105.4小时(4.4天)(95%CI 25.1至162.0,P < 0.001)。

结论

在8小时的急诊科暴露后,八分之一的独立/半独立老年人中观察到新发谵妄。一次谵妄发作会使住院时间增加4天,因此对患者具有重要影响,并可能通过有害的反馈循环导致急诊科拥挤。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5932/5855334/e3b14d077fe6/bmjopen-2017-018190f01.jpg

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