Pullicino Richard, Radon Mark, Biswas Shubhabrata, Bhojak Maneesh, Das Kumar
Neuroradiology Department, The Walton Centre NHS Foundation Trust, Lower Lane, L9 7LJ, Liverpool, UK.
Clin Neuroradiol. 2018 Jun;28(2):159-169. doi: 10.1007/s00062-018-0678-0. Epub 2018 Mar 9.
Over the past 3 years, gadolinium-based contrast agents have been linked to MRI signal changes in the brain, which have been found to be secondary to gadolinium deposition in the brain, particularly in the dentate nuclei and globus pallidus even in patients having an intact blood-brain barrier and a normal renal function. This tends to occur more in linear agents than with macrocyclic agents. Nonetheless, there has been no significant evidence that this has any clinical consequence. We reviewed the current evidence related to this new phenomenon and the precautionary approach taken by regulatory agencies.
在过去3年里，钆基造影剂已被发现与大脑中的磁共振成像（MRI）信号变化有关，即便在血脑屏障完整且肾功能正常的患者中，也发现这些变化是由钆在大脑中的沉积引起的，特别是在齿状核和苍白球。与大环类造影剂相比，线性造影剂更容易出现这种情况。然而，目前尚无显著证据表明这会产生任何临床后果。我们回顾了与这一新现象相关的现有证据以及监管机构采取的预防措施。
