Andrianjafy Tovo Mbolatiana, Ravaomanarivo Lala Harivelo, Ramanandraibe Voahangy Vestalys, Rakotondramanga Maonja Finaritra, Mavingui Patrick, Lemaire Marc
Laboratory International Associates, University of Antananarivo-University of Lyon 1, PO Box 906, Antananarivo, Madagascar.
Department of Entomology, University of Antananarivo, PO Box 906, Antananarivo, Madagascar.
J Chem Ecol. 2018 Mar;44(3):299-311. doi: 10.1007/s10886-018-0931-7. Epub 2018 Mar 10.
In recent years, a significant increase in mosquito-borne diseases has been recorded worldwide. Faced with the limitations of existing methods for controlling the vector mosquito population, the development of attractants to bait traps and repellents to limit host-vector contacts could be promising and environmentally-friendly control strategies. The purpose of this study was to evaluate the effect of hydroxycoumarins and their alkyls derivatives against Aedes albopictus, the main vector of several arboviruses. Synthesis, bioassays and field trials were carried out in Madagascar. The results showed that 3, 4 and 6-hydroxycoumarins are attractive to this mosquito, 4-hydroxycoumarin being the most effective both in the laboratory and under field conditions. In addition, a good synergistic effect was found with octenol to attract mosquitoes and especially Ae. albopictus in comparison to other mosquito species living in sympatry. On the contrary, the 4-s-butoxycoumarin and 4-s-pentoxycoumarin derivatives had a repellent effect with the former showing the most significant effect. Further optimization of the dose and structure of these products will be carried out in order to maximize their utility for the control of Ae. albopictus and other mosquitoes.
近年来，全球范围内蚊媒疾病显著增加。鉴于现有控制媒介蚊虫数量方法的局限性，开发用于诱捕器诱饵的引诱剂以及用于限制宿主与媒介接触的驱避剂可能是有前景且环保的控制策略。本研究的目的是评估羟基香豆素及其烷基衍生物对几种虫媒病毒的主要传播媒介白纹伊蚊的作用。在马达加斯加进行了合成、生物测定和田间试验。结果表明，3 - 羟基香豆素、4 - 羟基香豆素和6 - 羟基香豆素对白纹伊蚊具有吸引力，其中4 - 羟基香豆素在实验室和田间条件下均最为有效。此外，发现与辛醇具有良好的协同作用，可吸引蚊虫，尤其是与同域生活的其他蚊种相比对白纹伊蚊的吸引力更强。相反，4 - s - 丁氧基香豆素和4 - s - 戊氧基香豆素衍生物具有驱避作用，前者的效果最为显著。将对这些产品的剂量和结构进行进一步优化，以最大限度地发挥其在控制白纹伊蚊和其他蚊虫方面的效用。
