International Associated Laboratory, University of Antananarivo-Lyon 1, PO Box 906, Antananarivo, Madagascar.
Department of Entomology, University of Antananarivo, PO Box 906, Antananarivo, Madagascar.
Sci Rep. 2020 Feb 20;10(1):3048. doi: 10.1038/s41598-020-59822-6.
Mosquito-borne diseases like malaria are a major public health problem in tropical countries, such as Madagascar. Female Anopheles mosquito vectors the human malaria parasites (Plasmodium spp.) and is important indicator in malaria surveillance activities. Among the various means of vector control in Madagascar, the use of attractants for mass trapping of target species could be an alternative to insecticides. The aim of this study is to evaluate whether 4-hydroxycoumarin can be used as an attractant for anthropophilic Anopheles spp. vectors of malaria. For this, a field study was conducted using CDC light traps in the village of Ambohidray, Madagascar. 16 days of trapping was conducted and four replicates nights were performed for each product tested. 4-hydroxycoumarin, octenol and two types of blend of these products were tested. The results showed that 4-hydroxycoumarin (2 mg) have a significant attractive effect on Anopheles spp. and significant selectivity towards Anopheles gambiae s.l, and Anopheles mascarensis which are both significant malaria vectors in Madagascar. A synergy of 4-hydroxycoumarin with octenol was found to attract these mosquito vectors. A significant decrease in vector populations was observed during this experiment. These results suggest that 4-hydroxycoumarin could be useful for malaria surveillance and the control of vector populations.
蚊媒疾病（如疟疾）是马达加斯加等热带国家的主要公共卫生问题。雌性疟蚊是人类疟疾寄生虫（疟原虫属）的传播媒介，是疟疾监测活动中的重要指标。在马达加斯加的各种病媒控制手段中，利用引诱剂对目标物种进行大规模诱捕可能是一种替代杀虫剂的方法。本研究旨在评估 4-羟基香豆素是否可用作疟疾的嗜人按蚊等蚊媒的引诱剂。为此，在马达加斯加的安博希德拉伊村进行了一项使用 CDC 诱捕器的现场研究。进行了 16 天的诱捕，并对每种测试产品进行了四组重复夜间测试。测试了 4-羟基香豆素、辛醇和这两种产品的两种混合物。结果表明，4-羟基香豆素（2mg）对按蚊属具有显著的吸引力，对马达加斯加的重要疟疾传播媒介冈比亚按蚊和曼氏按蚊具有显著的选择性。发现 4-羟基香豆素与辛醇具有协同作用，可以吸引这些蚊子媒介。在实验过程中观察到媒介种群数量显著减少。这些结果表明，4-羟基香豆素可用于疟疾监测和控制媒介种群。
