Francis A J, Home P D, Walford S, Alberti K G, Mann N, Reeves W G
Diabet Med. 1985 Mar;2(2):89-94. doi: 10.1111/j.1464-5491.1985.tb00607.x.
A rise in blood glucose concentration at the end of the night, and consequent morning hyperglycaemia, are well recognized events in some diabetic patients. In 94 patients on twice daily insulin injections we have examined the prevalence and extent of morning hyperglycaemia, and its relation to control, insulin therapy, and insulin antibody levels. Blood glucose reached the highest level of the day before or after breakfast in 83% of patients, and in 50% this value was 2 mmol/l greater than any other time of day. Patients with higher fasting concentrations did not have worse blood glucose control over the rest of the day. No correlation was found between fasting blood glucose concentrations and the evening dose of intermediate acting insulin or the level of insulin antibodies. No consistent change in fasting blood glucose concentrations occurred with changes in antibody levels in patients switched between pork and beef insulin. Morning hyperglycaemia was as common with both insulin species. Pre- and post-breakfast hyperglycaemia is common and significant in insulin-treated diabetic patients. It is not directly related to diabetic control at other times of the day, and is independent of insulin species and insulin antibody levels.
夜间结束时血糖浓度升高以及随之而来的清晨高血糖，在一些糖尿病患者中是广为人知的现象。在94例每日注射两次胰岛素的患者中，我们研究了清晨高血糖的发生率和程度，及其与血糖控制、胰岛素治疗和胰岛素抗体水平的关系。83%的患者血糖在早餐前或早餐后达到一天中的最高水平，其中50%患者的该值比一天中的其他任何时间高2 mmol/l。空腹血糖浓度较高的患者在一天中的其余时间里血糖控制情况并未更差。空腹血糖浓度与中效胰岛素的夜间剂量或胰岛素抗体水平之间未发现相关性。在使用猪胰岛素和牛胰岛素之间切换的患者中，空腹血糖浓度并未随抗体水平的变化而出现一致的改变。两种胰岛素制剂导致的清晨高血糖情况同样常见。早餐前和早餐后的高血糖在接受胰岛素治疗的糖尿病患者中很常见且较为显著。它与一天中其他时间的糖尿病控制并无直接关系，并且与胰岛素制剂种类和胰岛素抗体水平无关。
