Gibb D M, Foot A B, May B, Parish H, Strang S, Grant D B, Dunger D B
Hospital for Sick Children, London.
Arch Dis Child. 1990 Dec;65(12):1334-7. doi: 10.1136/adc.65.12.1334.
Fifty two children with insulin dependent diabetes mellitus were randomised to receive human isophane or lente insulin preparations in combination with soluble insulin in a double blind trial. Patients were seen every two months, and crossed over after four months of treatment. Control assessed by glycated haemoglobin was significantly lower in children on human isophane insulin, but fasting blood glucose and fructosamine concentrations and the number of episodes of hypoglycaemia were similar on both regimens. In five children on twice daily insulin regimens, insulin profiles throughout a 24 hour period demonstrated greater variability on lente compared with isophane insulin despite identically administered insulin doses. A questionnaire completed at the end of the study showed that two thirds of the children and/or their parents preferred the isophane insulin, and they gave perceived improvement of metabolic control as the major reason for their choice.
52名胰岛素依赖型糖尿病儿童在一项双盲试验中被随机分组，接受人低精蛋白胰岛素或慢胰岛素锌悬液制剂与可溶性胰岛素联合治疗。每两个月对患者进行一次检查，并在治疗四个月后进行交叉治疗。通过糖化血红蛋白评估的对照组中，使用人低精蛋白胰岛素的儿童血糖控制明显更低，但两种治疗方案的空腹血糖、果糖胺浓度以及低血糖发作次数相似。在5名接受每日两次胰岛素治疗方案的儿童中，尽管胰岛素剂量相同，但在24小时内，慢胰岛素锌悬液的胰岛素曲线变化比低精蛋白胰岛素更大。研究结束时完成的一份调查问卷显示，三分之二的儿童和/或其父母更喜欢低精蛋白胰岛素，他们将代谢控制的明显改善作为选择的主要原因。
