Enander I, Ulfgren A K, Nygren H, Holmdahl R, Klareskog L, Larsson P, Ahlstedt S
Int Arch Allergy Appl Immunol. 1987;82(3-4):361-3. doi: 10.1159/000234227.
Epicutaneous sensitization with picrylchloride (PiCl) induced a strongly delayed hypersensitivity (DH) reaction in mice. Local challenge in the airways of these mice resulted in increased numbers of mononuclear cells, mast cells and mucus cells. Depletion of T helper cells in vivo by treatment with monoclonal antibody (GK 1.5) inhibited the DH reaction. This treatment also resulted in a decrease in the number of mononuclear and mucus cells in the lung after intranasal challenge. The DH reaction was transferred to recipients with immune lymph node cells and spleen cells from mice sensitized epicutaneously with PiCl. The recipient mice also showed a slight increase in the number of mononuclear cells in the lung after intranasal challenge. These results indicate that T cells are not only involved in the DH reaction but also in the accompanying lung reaction.
用苦味酸氯（PiCl）进行表皮致敏可在小鼠中诱导强烈的迟发型超敏反应（DH）。对这些小鼠的气道进行局部激发会导致单核细胞、肥大细胞和黏液细胞数量增加。用单克隆抗体（GK 1.5）在体内耗尽辅助性T细胞可抑制DH反应。这种处理还导致鼻内激发后肺中单核细胞和黏液细胞数量减少。用经PiCl表皮致敏的小鼠的免疫淋巴结细胞和脾细胞将DH反应转移给受体。受体小鼠在鼻内激发后肺中单核细胞数量也略有增加。这些结果表明，T细胞不仅参与DH反应，还参与伴随的肺部反应。
