a Department of Experimental Medicine and Surgery , University of Rome Tor Vergata , Rome , Italy.
b Department of Experimental Medicine, Unit of Pharmacology , University of Campania Luigi Vanvitelli , Naples , Italy.
Expert Opin Drug Metab Toxicol. 2018 Apr;14(4):435-446. doi: 10.1080/17425255.2018.1449833. Epub 2018 Mar 12.
Our understanding of whether and/or how ethnicity influences pharmacological response to asthma therapies is still very scarce. A possible explanation for the increased asthma treatment failures observed in ethnic and racial minorities receiving asthma therapies is that some of these groups may have a pharmacogenomic predisposition to either nonresponse or to adverse response with a specific class of drugs. However, the effects of ethnicity on pharmacological response to asthma therapies are also, and mainly, determined by socioeconomic and environmental factors to a varying extent, depending on the ethnic groups. Areas covered: Genetic, socioeconomic and environmental factors that can affect the pharmacotherapeutic responses to asthma medications and their link(s) to race/ethnicity have been examined and critically discussed. Expert opinion: Differences in genetic ancestry are definitely non-modifiable factors, but socioeconomic and environmental disadvantages are all factors that can be modified. It is likely that improved outcomes may be achieved when tailored and multifaceted approaches that include home, school, and clinician-based interventions are implemented. Consequently, it is critical to determine if a clinical intervention programme combined with implementation strategies that attempt to reduce inequalities can reduce asthma disparities, including the influence of ethnicity and race on pharmacological response to asthma therapies.
我们对于种族是否以及如何影响哮喘治疗药物的药理反应知之甚少。在接受哮喘治疗的少数族裔和少数民族中，观察到哮喘治疗失败的增加，一个可能的解释是，这些群体中的一些人可能具有对特定类药物的药理反应无应答或不良反应的遗传易感性。然而，种族对哮喘治疗药物的药理反应的影响也在很大程度上取决于遗传背景以外的社会经济和环境因素，具体取决于不同的种族群体。涵盖领域：遗传、社会经济和环境因素会影响哮喘药物治疗的药效反应及其与种族的联系，本文对这些因素进行了考察和批判性讨论。专家意见：遗传背景的差异是不可改变的因素，但社会经济和环境劣势都是可以改变的因素。当实施基于家庭、学校和临床医生的干预措施的定制化和多方面方法时，可能会实现更好的结果。因此，当实施旨在减少不平等的临床干预方案和实施策略时，确定是否可以减少哮喘差异，包括种族和民族对哮喘治疗药物的药理反应的影响，这一点至关重要。
