Drake Katherine A, Galanter Joshua M, Burchard Esteban González
Department of Biopharmaceutical Sciences, UCSF/Lung Biology Center, University of California, San Francisco, CA 94143-2911, USA.
Pharmacogenomics. 2008 Apr;9(4):453-62. doi: 10.2217/14622416.9.4.453.
Asthma is a common but complex respiratory disease caused by the interaction of genetic and environmental factors. Significant racial and ethnic disparities in prevalence, mortality and drug response have been described. These disparities may be explained by racial and ethnic-specific variation in genetic, environmental, social and psychological risk factors. In addition, race, ethnicity and social class are important proxies for unmeasured factors that influence health outcomes. Herein, we review salient differences in the etiologies of asthma by race, ethnicity and social class, and argue for their continued use as variables in asthma research.
哮喘是一种常见但复杂的呼吸系统疾病，由遗传和环境因素相互作用引起。已有研究描述了哮喘在患病率、死亡率和药物反应方面存在显著的种族和民族差异。这些差异可能是由遗传、环境、社会和心理风险因素中种族和民族特异性的变异所导致的。此外，种族、民族和社会阶层是影响健康结果的未测量因素的重要替代指标。在此，我们综述了哮喘病因在种族、民族和社会阶层方面的显著差异，并主张在哮喘研究中继续将它们用作变量。
