Machado-Duque Manuel E, Castaño-Montoya Juan Pablo, Medina-Morales Diego A, Castro-Rodríguez Alejandro, González-Montoya Alexandra, Machado-Alba Jorge E
1 Grupo de Investigación en Farmacoepidemiología y Farmacovigilancia, Universidad Tecnológica de Pereira-Audifarma S.A., Pereira, Colombia.
J Geriatr Psychiatry Neurol. 2018 Mar;31(2):63-69. doi: 10.1177/0891988718757370. Epub 2018 Mar 11.
BACKGROUND/OBJECTIVE: To determine the association between the use of anticholinergic drugs and the risk of falls with hip fracture in a population older than 60 years.
A case-control study in patients older than 60 years with a diagnosis of hip fracture. All drugs dispensed during the previous 30 days were identified. Sociodemographic, clinical, pharmacological (drugs according to the Anticholinergic Risk Scale [ARS]), and polypharmacy variables were analyzed.
Falls with hip fracture and type of drug according to the ARS.
A total of 300 patients with hip fracture and 600 controls were included. The mean age was 81.6 ± 8.9 years, with female predominance (71.3%). The use of drugs with moderate (odds ratio [OR]: 1.97, 95% confidence interval [CI]: 1.19-3.27) or high ARS scores (OR: 1.83, 95% CI: 1.13-2.96) increased the probability of fracture.
There was an association between the use of drugs with anticholinergic properties and the probability of hip fracture in elderly patients and it was possible to establish the level of risk.
背景/目的：确定60岁以上人群中使用抗胆碱能药物与髋部骨折跌倒风险之间的关联。
对60岁以上诊断为髋部骨折的患者进行病例对照研究。确定前30天内使用的所有药物。分析社会人口统计学、临床、药理学（根据抗胆碱能风险量表[ARS]分类的药物）和多重用药变量。
髋部骨折跌倒情况及根据ARS分类的药物类型。
共纳入300例髋部骨折患者和600例对照。平均年龄为81.6±8.9岁，女性占多数（71.3%）。使用ARS评分为中度（比值比[OR]：1.97，95%置信区间[CI]：1.19 - 3.27）或高度（OR：1.83，95%CI：1.13 - 2.96）的药物会增加骨折概率。
老年患者使用具有抗胆碱能特性的药物与髋部骨折概率之间存在关联，且有可能确定风险水平。
