The University of Adelaide, Adelaide Medical School, Discipline of Psychiatry, Adelaide, Australia.
The University of Adelaide, Adelaide Medical School, Discipline of Anatomy and Pathology, Adelaide, Australia.
J Affect Disord. 2018 Jul;234:180-192. doi: 10.1016/j.jad.2018.02.058. Epub 2018 Feb 24.
Regular exercise in adults improves depressive symptoms (DS) and major depressive disorder (MDD), however the clinical effects of ceasing exercise are largely unknown.
Seven databases were searched from inception to December 2017. Eligibility criteria included English language studies investigating the effects of ceasing exercise on DS or MDD in regularly active adults with or without prior DS or MDD. Blood based markers related to exercise cessation (EC) were assessed, if recorded. Studies investigating exercise follow-up periods were excluded.
No studies investigated EC in MDD. Six studies including two RCTS and three studies investigating neurogenic and immune biological markers associated with DS met inclusion criteria (152 healthy adults, females n = 50/32.89%). Compared to baseline, EC increased DS after three days, one week, and two weeks. Female participants had significantly more DS than male participants. Following EC, no changes in brain derived neurotrophic factor (BDNF) or tumour necrosis factor alpha (TNF) were evident, however C-reactive protein (CRP) at week one and interleukin 6 (IL6) at week two were reduced.
Quality concerns including risks of attrition and reporting bias limit our confidence in these results.
Ceasing regular exercise increases DS in healthy adults, with greater DS in females than males. Contrary to the cytokine/inflammatory hypothesis of depression, DS were associated with reduced CRP and IL6 and without increased TNF. High quality trials are needed to extend this field of research in both healthy and MDD populations.
成年人经常锻炼可以改善抑郁症状（DS）和重度抑郁症（MDD），然而，停止锻炼的临床效果在很大程度上尚不清楚。
从成立到 2017 年 12 月，我们在七个数据库中进行了搜索。纳入标准包括：研究定期运动对有或无抑郁症状或 MDD 的成年人 DS 或 MDD 的影响；如果记录了与运动停止相关的血液标志物，则将其纳入研究。排除了研究运动随访期的研究。
没有研究调查 MDD 中的 EC。有六项研究（两项 RCT 和三项与 DS 相关的神经发生和免疫生物学标志物的研究）符合纳入标准（152 名健康成年人，女性 n=50/32.89%）。与基线相比，EC 在三天、一周和两周后均增加了 DS。女性参与者的 DS 明显多于男性参与者。EC 后，BDNF 或 TNF 无明显变化，但 CRP 在一周时和 IL6 在两周时降低。
质量问题，包括失访和报告偏倚的风险，限制了我们对这些结果的信心。
停止经常锻炼会增加健康成年人的 DS，女性的 DS 比男性更大。与抑郁的细胞因子/炎症假说相反，DS 与 CRP 和 IL6 减少有关，而 TNF 没有增加。需要高质量的试验来扩展这一领域在健康人群和 MDD 人群中的研究。
