Li Mi, Feng Lei, Liu Xingwang, Zhang Ming, Fu Bingbing, Wang Gang, Lu Shengfu, Zhong Ning, Hu Bin
1 Department of Automation, Faculty of Information Technology, Beijing University of Technology, Beijing, China.
3 The Beijing International Collaboration Base on Brain Informatics and Wisdom Services, Beijing, China.
J Int Med Res. 2018 May;46(5):1734-1746. doi: 10.1177/0300060518758225. Epub 2018 Mar 12.
Objective This study was performed to examine the working memory (WM) encoding and retrieval abilities in patients with major depressive disorder (MDD) and determine whether a mood-congruent memory effect is present. Methods The modified Sternberg WM paradigm with positive, negative, and neutral emotional pictures was used to investigate the WM abilities of 26 patients with MDD and 26 healthy controls (HCs). Results No significant difference in picture WM was found between the MDD and HC groups; however, the accuracy of picture position WM was significantly lower and the response time was significantly longer in the MDD than HC group, regardless of the picture or position WM. Additionally, in the MDD group, the accuracy of negative picture/position WM was significantly higher than that of positive picture/position WM. Conclusions These results suggest that in patients with MDD, spatial WM impairment was more severe than object WM. In addition, these patients' WM retrieval was impaired, resulting in a decrease in WM retrieval ability, which may be an important cause of the slow thought in patients with MDD. Moreover, patients with depression have a mood-congruent memory effect, which may be an important factor in the occurrence and maintenance of depression.
目的 本研究旨在检测重度抑郁症（MDD）患者的工作记忆（WM）编码和检索能力，并确定是否存在情绪一致性记忆效应。方法 采用改良的Sternberg WM范式，使用正性、负性和中性情绪图片，对26例MDD患者和26名健康对照者（HCs）的WM能力进行研究。结果 MDD组和HC组在图片WM方面未发现显著差异；然而，无论图片或位置WM，MDD组图片位置WM的准确性显著低于HC组，反应时间显著长于HC组。此外，在MDD组中，负性图片/位置WM的准确性显著高于正性图片/位置WM。结论 这些结果表明，MDD患者的空间WM损害比客体WM更严重。此外，这些患者的WM检索受损，导致WM检索能力下降，这可能是MDD患者思维迟缓的重要原因。此外，抑郁症患者存在情绪一致性记忆效应，这可能是抑郁症发生和维持的重要因素。
