Wang Yu-Fang, Li Jiao-Xing, Sun Xun-Sha, Lai Rong, Sheng Wen-Li
Neurology Department, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
J Int Med Res. 2018 May;46(5):1826-1838. doi: 10.1177/0300060517752996. Epub 2018 Mar 12.
Objective We aimed to evaluate the association between serum uric acid levels at the onset and prognostic outcome in patients with acute ischaemic stroke. Methods We retrospectively analysed the outcomes of 1166 patients with ischaemic stroke who were hospitalized in our centre during August 2008 to November 2012. Correlations of serum uric acid levels and prognostic outcomes were analysed. Results Men had higher serum uric acid levels and better neurological functional outcomes compared with women. There was a strong negative correlation between serum uric acid levels and unfavourable neurological functional outcomes. Generalized estimated equation analysis showed that a higher serum uric acid level (>237 µmol/L) was a protective factor for neurological functional outcome in male, but not female, patients. Among five trial of ORG 10172 in acute stroke treatment classification subtypes, only patients with the large-artery atherosclerosis subtype had a significant protective effect of serum uric acid levels on neurological outcome. Conclusions Our study shows that high serum uric acid levels are a significant protective factor in men and in the large-artery atherosclerosis subtype in patients with ischaemic stroke. This is helpful for determining the prognostic value of serum uric acid levels for neurological outcome of acute ischaemic stroke.
目的 我们旨在评估急性缺血性脑卒中患者发病时血清尿酸水平与预后结果之间的关联。方法 我们回顾性分析了2008年8月至2012年11月期间在本中心住院的1166例缺血性脑卒中患者的结局。分析血清尿酸水平与预后结果的相关性。结果 男性血清尿酸水平高于女性，神经功能结局也优于女性。血清尿酸水平与不良神经功能结局之间存在强烈的负相关。广义估计方程分析显示，较高的血清尿酸水平（>237 µmol/L）是男性而非女性患者神经功能结局的保护因素。在急性卒中治疗分类亚型的五项ORG 10172试验中，仅大动脉粥样硬化亚型患者的血清尿酸水平对神经结局有显著保护作用。结论 我们的研究表明，高血清尿酸水平是缺血性脑卒中男性患者以及大动脉粥样硬化亚型患者的重要保护因素。这有助于确定血清尿酸水平对急性缺血性脑卒中神经结局的预后价值。
