Zhou Qingxin, Yang Qingqing, Shi Shuyuan, Li Pei, Sun Feng
Department of Epidemiology and Biostatistics, Peking University School of Public Health, Beijing 100191, China.
Beijing Da Xue Xue Bao Yi Xue Ban. 2024 Aug 18;56(4):693-699. doi: 10.19723/j.issn.1671-167X.2024.04.024.
To investigate the association between serum uric acid, pulmonary function and airflow obstruction in Chinese Taiwan healthy subjects.
All the cross-sectional analysis was performed in the population over 40 years old using the physical examination data of Chinese Taiwan MJ Health Resource Center between 1996 and 2016 stratification by gender. The correlation analyses between serum uric acid were done and multivariate Logistic regression analysis was used to explore the effect of serum uric acid on airflow obstruction.
A total of 35 465 people were included in the study, including 16 411 men and 19 054 women. Among them, the serum uric acid concentration of men was higher than that of women, and the serum uric acid concentration of the people with airflow obstruction was higher than that of the people without airflow obstruction. There was a negative correlation between serum uric acid level and the forced expiratory volume in one second (FEV1) and the force vital capacity (FVC) in women ( < 0.05), but in men the correlation didn' t exist (>0.05). After adjusting for age, education, smoking status, drinking status, work strength, body mass index, history of cough, history of hypertension, history of diabetes, history of dyslipidemia, white blood cells and blood albumin, the airflow obstruction in women was more likely to exist with the serum uric acid elevated (=1. 12, 95%: 1.02-1.22, < 0.05). The results showed that women with hyperuricemia were more likely to have airflow obstruction than those without hyperuricemia (=1.36, 95%: 1.06-1.75, < 0.05). There was no correlation between serum uric acid concentration and airflow obstruction in men (=1.04, 95%: 0.96-1.13, >0.05), also the hyperuricemia and airflow obstruction (=1.12, 95%: 0.89-1.39, >0.05).
There is a negative correlation between serum uric acid and FEV1 and FVC in relatively healthy women, and there is an association between elevated serum uric acid and airflow obstruction in women, but not in men. Further prospective studies are needed to explore whether high serum uric acid level can increase the risk of airflow obstruction.
探讨中国台湾健康受试者血清尿酸、肺功能与气流受限之间的关联。
利用中国台湾 MJ 健康资源中心 1996 年至 2016 年 40 岁以上人群的体检数据按性别分层进行所有横断面分析。对血清尿酸进行相关性分析，并采用多因素 Logistic 回归分析探讨血清尿酸对气流受限的影响。
本研究共纳入 35465 人，其中男性 16411 人，女性 19054 人。其中，男性血清尿酸浓度高于女性，气流受限者的血清尿酸浓度高于无气流受限者。女性血清尿酸水平与一秒用力呼气容积（FEV1）和用力肺活量（FVC）呈负相关（P<0.05），但男性不存在这种相关性（P>0.05）。在调整年龄、教育程度、吸烟状况、饮酒状况、工作强度、体重指数、咳嗽史、高血压史、糖尿病史、血脂异常史、白细胞和血白蛋白后，女性血清尿酸升高时更易出现气流受限（OR = 1.12，95%CI：1.02 - 1.22，P < 0.05）。结果显示，高尿酸血症女性比无高尿酸血症女性更易出现气流受限（OR = 1.36，95%CI：1.06 - 1.75，P < 0.05）。男性血清尿酸浓度与气流受限无相关性（OR = 1.04，95%CI：0.96 - 1.13，P > 0.05），高尿酸血症与气流受限也无相关性（OR = 1.12，95%CI：0.89 - 1.39，P > 0.05）。
在相对健康的女性中，血清尿酸与 FEV1 和 FVC 呈负相关，血清尿酸升高与女性气流受限有关，但男性并非如此。需要进一步的前瞻性研究来探讨高血清尿酸水平是否会增加气流受限的风险。
