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针对残疾的选择:选择与调整

Selecting for Disabilities: Selection Versus Modification.

作者信息

Shaw Joshua

机构信息

a Penn State Erie, The Behrend College , Erie , PA , USA.

出版信息

New Bioeth. 2018 Apr;24(1):44-56. doi: 10.1080/20502877.2018.1441671.

DOI:10.1080/20502877.2018.1441671
PMID:29529983
Abstract

This essay considers one argument used to defend parents who use preimplantation genetic diagnosis (PGD) to select for deafness and other disabilities. Some bioethicists have argued that a distinction should be drawn between genetically modifying embryos to possess disabilities and using PGD to select embryos that already present markers of them, and that the former is unethical because it inflicts avoidable harms onto the resulting children, whereas the latter is permissible because it allows children with potentially impaired abilities to exist. This essay raises doubts about whether a meaningful moral distinction can be drawn between modification and selection. Arguments which distinguish modification from selection can be understood in two ways. One is to read them as presenting a No Harm, No Foul argument. Another is to read them as presenting a Harming Versus Letting Be argument. Neither succeeds, however, either in establishing a meaningful moral distinction between modification and selection, or in showing that the second is morally permissible in contradistinction to the first.

摘要

本文探讨了一种用于为那些利用植入前基因诊断(PGD)来选择耳聋及其他残疾胎儿的父母进行辩护的观点。一些生物伦理学家认为,在通过基因改造使胚胎带有残疾与利用PGD选择那些已带有残疾标记的胚胎之间应有所区分,前者是不道德的,因为它给所产生的孩子带来了可避免的伤害,而后者是允许的,因为它让那些能力可能受损的孩子得以出生。本文对是否能在改造与选择之间划出有意义的道德界限提出了质疑。区分改造与选择的观点可以从两种方式来理解。一种是将它们视为提出了一种“无伤害则无过错”的观点。另一种是将它们视为提出了一种“伤害与放任”的观点。然而,这两种方式都未能成功地在改造与选择之间确立有意义的道德区分,也未能表明与前者相反,后者在道德上是允许的。

相似文献

1
Selecting for Disabilities: Selection Versus Modification.针对残疾的选择:选择与调整
New Bioeth. 2018 Apr;24(1):44-56. doi: 10.1080/20502877.2018.1441671.
2
Is it ever morally permissible to select for deafness in one's child?为自己的孩子选择失聪在道德上是否永远是不被允许的?
Med Health Care Philos. 2020 Mar;23(1):3-15. doi: 10.1007/s11019-019-09922-6.
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Disabled by Design: Justifying and Limiting Parental Authority to Choose Future Children with Pre-Implantation Genetic Diagnosis.设计导致的残疾:为通过植入前基因诊断选择未来子女的父母权威进行辩护及加以限制
Kennedy Inst Ethics J. 2017;27(4):475-500. doi: 10.1353/ken.2017.0039.
4
Why Human Germline Editing is More Problematic than Selecting Between Embryos: Ethically Considering Intergenerational Relationships.为何人类生殖系编辑比胚胎选择更具问题:从伦理角度考量代际关系
New Bioeth. 2018 Apr;24(1):9-25. doi: 10.1080/20502877.2018.1441669.
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In defense of prenatal genetic interventions.为产前基因干预辩护。
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6
There is a difference between selecting a deaf embryo and deafening a hearing child.选择一个失聪胚胎和使一个听力正常的孩子失聪是有区别的。
J Med Ethics. 2004 Oct;30(5):510-2. doi: 10.1136/jme.2002.001891.
7
Who should pay for bad genes?不良基因该由谁来买单?
Calif Law Rev. 2002 Oct;90(5):1345-414.
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Procreative beneficence: why we should select the best children.生殖善行:为何我们应该挑选最优的孩子。
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Subsidizing PGD: The Moral Case for Funding Genetic Selection.补贴 PGD:为基因选择提供资金的道德理由。
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10
[Ethical aspects of preimplantation genetic diagnosis (PGD)].[胚胎植入前遗传学诊断(PGD)的伦理问题]
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引用本文的文献

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J Assist Reprod Genet. 2024 May;41(5):1153-1171. doi: 10.1007/s10815-024-03076-y. Epub 2024 Mar 21.
2
Prenatal Diagnosis and Pregnancy Termination in Jewish and Muslim Women with a Deaf Child in Israel.以色列犹太和穆斯林妇女怀有失聪胎儿时的产前诊断与终止妊娠情况
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Prenatal Testing and Pregnancy Termination Among Muslim Women Living in Israel Who Have Given Birth to a Child with a Genetic Disease.
以色列穆斯林妇女在生育患有遗传疾病的孩子后进行产前检查和终止妊娠的情况。
J Relig Health. 2023 Oct;62(5):3215-3229. doi: 10.1007/s10943-023-01904-6. Epub 2023 Sep 16.
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Germline genome editing versus preimplantation genetic diagnosis: Is there a case in favour of germline interventions?胚系基因组编辑与胚胎植入前遗传学诊断:胚系干预有其合理之处吗?
Bioethics. 2020 Jan;34(1):60-69. doi: 10.1111/bioe.12635. Epub 2019 Aug 25.