Department of Neurology and Institute of Neurology, Ruijin Hospital affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
Department of Neurology and Institute of Neurology, Ruijin Hospital affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
Sleep Med. 2018 Apr;44:38-44. doi: 10.1016/j.sleep.2018.01.006. Epub 2018 Jan 31.
Increasing evidence indicates a strong association between rapid eye movement sleep behavior disorder (RBD) and Parkinson's disease - cognitive impairment (PD-CI). Numerous longitudinal and cross-sectional studies have shown that RBD may be an important risk factor and predictor of Parkinson's disease - mild cognitive impairment (PD-MCI) and Parkinson's disease dementia (PDD); which may be explained by the association of mechanisms between RBD and PD-CI, including neurotransmitter alterations, genetic mutation, neuroinflammation, alpha-synuclein inclusion, abnormal cerebral metabolism and cortical activity slowing. Understanding the role of RBD in cognition of PD, we may predict and prevent the presence of PD-CI. The purpose of our comprehensive narrative review was to investigate the role of RBD in cognition of PD patients and its possible mechanism with lights from clinical epidemiological evidence, neuroimaging and electrophysiology studies.
越来越多的证据表明，快速眼动睡眠行为障碍（RBD）与帕金森病-认知障碍（PD-CI）之间存在很强的关联。许多纵向和横断面研究表明，RBD 可能是帕金森病-轻度认知障碍（PD-MCI）和帕金森病痴呆（PDD）的重要危险因素和预测因素；这可以用 RBD 与 PD-CI 之间的机制关联来解释，包括神经递质改变、基因突变、神经炎症、α-突触核蛋白包涵体、异常脑代谢和皮质活动减慢。了解 RBD 在 PD 认知中的作用，我们可以预测和预防 PD-CI 的发生。我们进行全面叙述性综述的目的是研究 RBD 在 PD 患者认知中的作用及其可能的机制，并从临床流行病学证据、神经影像学和电生理学研究的角度进行探讨。
