Lee D A, Lee H J, Park K M
Department of Neurology, Haeundae Paik Hospital, Inje University College of Medicine, Haeundae-ro 875, Haeundae-gu, Busan 48108 Republic of Korea.
Department of Radiology, Haeundae Paik Hospital, Inje University College of Medicine, Haeundae-gu, Busan Republic of Korea.
Sleep Biol Rhythms. 2022 Dec 29;21(2):233-240. doi: 10.1007/s41105-022-00440-2. eCollection 2023 Apr.
This study aimed to investigate the alterations in limbic structure volumes and limbic covariance network in patients with isolated rapid eye movement (REM) sleep behavior disorder (iRBD) and to compare them with healthy controls. We retrospectively enrolled 35 patients with iRBD and 35 healthy controls who underwent three-dimensional T1-weighted brain MRI. Volumetric analysis of subcortical limbic structures, including the hippocampus, amygdala, thalamus, mammillary body, hypothalamus, basal forebrain, septal nuclei, fornix, and nucleus accumbens, was performed. Furthermore, the limbic covariance network was examined using graph theory based on the limbic structure volumes. Some of the limbic structure volumes differed significantly. The right amygdala and hypothalamus volumes were lower in the patients with iRBD than in the healthy controls (0.101% vs. 0.114%, = 0.016, and 0.027% vs. 0.030%, = 0.045, respectively). However, there were no significant differences in the limbic covariance network between the groups. This study demonstrated that the volumes of the right amygdala and hypothalamus are lower in patients with iRBD, even without cognitive impairments, than in healthy controls. However, there were no significant differences in the limbic covariance network between the groups. The involvements of the limbic structures could be related to the conversion to neurodegenerative diseases in patients with iRBD.
本研究旨在调查孤立性快速眼动（REM）睡眠行为障碍（iRBD）患者的边缘系统结构体积和边缘系统协方差网络的变化，并将其与健康对照进行比较。我们回顾性纳入了35例iRBD患者和35例接受三维T1加权脑MRI检查的健康对照。对包括海马体、杏仁核、丘脑、乳头体、下丘脑、基底前脑、隔核、穹窿和伏隔核在内的皮质下边缘系统结构进行了体积分析。此外，基于边缘系统结构体积，使用图论检查了边缘系统协方差网络。一些边缘系统结构体积存在显著差异。iRBD患者的右侧杏仁核和下丘脑体积低于健康对照（分别为0.101%对0.114%，P = 0.016；以及0.027%对0.030%，P = 0.045）。然而，两组之间的边缘系统协方差网络没有显著差异。本研究表明，即使没有认知障碍，iRBD患者的右侧杏仁核和下丘脑体积也低于健康对照。然而，两组之间的边缘系统协方差网络没有显著差异。边缘系统结构的受累可能与iRBD患者向神经退行性疾病的转化有关。
