Walters J R, Bergstrom D A, Carlson J H, Chase T N, Braun A R
Science. 1987 May 8;236(4802):719-22. doi: 10.1126/science.2953072.
D1 and D2 dopamine receptors exert synergistic effects on the firing rates of basal ganglia neurons and on the expression of stereotyped behavior in rats. Moreover, the ability of D2 agonists to induce changes in basal ganglia single unit activity and spontaneous motor activity is dependent upon the presence of endogenous dopamine to stimulate D1 receptors; in rats treated with alpha-methyl-rho-tyrosine to reduce endogenous dopamine levels, the neurophysiological and behavioral effects of the D2 agonist quinpirole are significantly attenuated, while the effects of nonselective agonists like apomorphine, which stimulate both D1 and D2 receptors, or combinations of a D2 agonist and a D1 agonist are not attenuated. Thus, the previously held view that D2 receptors alone are responsible for evoking the changes in behavior and basal ganglia output induced by nonselective dopamine agonists and endogenous dopamine is not supported by these results, which indicate that these phenomena require concurrent stimulation of both dopamine receptor subtypes.
D1和D2多巴胺受体对大鼠基底神经节神经元的放电频率以及刻板行为的表达具有协同作用。此外，D2激动剂诱导基底神经节单单位活动和自发运动活动变化的能力取决于内源性多巴胺的存在以刺激D1受体；在用α-甲基-对酪氨酸处理以降低内源性多巴胺水平的大鼠中，D2激动剂喹吡罗的神经生理和行为效应显著减弱，而刺激D1和D2受体的非选择性激动剂如阿扑吗啡或D2激动剂与D1激动剂组合的效应则未减弱。因此，这些结果不支持之前认为仅D2受体负责引发非选择性多巴胺激动剂和内源性多巴胺诱导的行为和基底神经节输出变化的观点，这些结果表明这些现象需要同时刺激两种多巴胺受体亚型。
