Dalimunthe Dina Arwina, Siregar Remenda, Tanjung Chairiyah
Department of Dermatology and Venereology, Faculty of Medicine, Sumatera Utara University, Medan, Indonesia.
Open Access Maced J Med Sci. 2018 Feb 11;6(2):326-329. doi: 10.3889/oamjms.2018.074. eCollection 2018 Feb 15.
Common warts are skin diseases caused by human papillomavirus. Several treatment modalities available for common warts, two of them are electrodesiccation with curettage and application of 80% phenol solution.
This study aims to compare clinical efficacy between these two modalities.
Open clinical trial was conducted at Dr Pirngadi General Hospital Medan and H. Adam Malik General Hospital Medan from February to June 2013 on 17 patients with multiple common warts. Both treatments began and applied simultaneously on the same day on each patient.
Cure rate was higher in electrodesiccation with curettage (76.5%, 100%) compared to the application of 80% phenol solution (11.8%, 64.7%) on three weeks and six weeks of follow up. Statistical analysis showed a significant difference of common warts cure rate between electrodesiccation with curettage and application of 80% phenol solution after three weeks (p < 0.001) and six weeks (p = 0.018) of treatment.
As a conclusion, electrodesiccation with curettage has higher cure rate than the application of 80% phenol solution on the treatment of common warts. Further study is needed to find out the best concentration and time interval for application of phenol solution to improve its clinical efficacy as an alternative treatment of choice for common warts.
寻常疣是由人乳头瘤病毒引起的皮肤病。寻常疣有多种治疗方式,其中两种是刮除术联合电干燥法以及应用80%苯酚溶液。
本研究旨在比较这两种治疗方式的临床疗效。
2013年2月至6月,在棉兰市皮尔恩加迪综合医院和棉兰市H.亚当·马利克综合医院对17例患有多发性寻常疣的患者进行了开放性临床试验。两种治疗在同一天开始并同时应用于每位患者。
在随访三周和六周时,刮除术联合电干燥法的治愈率(分别为76.5%、100%)高于应用80%苯酚溶液的治愈率(分别为11.8%、64.7%)。统计学分析显示,治疗三周(p < 0.001)和六周(p = 0.018)后,刮除术联合电干燥法与应用80%苯酚溶液治疗寻常疣的治愈率存在显著差异。
总之,在寻常疣治疗中,刮除术联合电干燥法的治愈率高于应用80%苯酚溶液。需要进一步研究以找出苯酚溶液应用的最佳浓度和时间间隔,以提高其作为寻常疣替代治疗选择的临床疗效。