Leong Derek, Sovari Ali A, Ehdaie Ashkan, Chakravarty Tarun, Liu Qiang, Jilaihawi Hasan, Makkar Rajendra, Wang Xunzhang, Cingolani Eugenio, Shehata Michael
Cedars-Sinai Heart Institute, 8700 Beverly Blvd, Suite 5512, Los Angeles, CA, 90048, USA.
J Interv Card Electrophysiol. 2018 Jun;52(1):111-116. doi: 10.1007/s10840-018-0345-z. Epub 2018 Mar 12.
Damage to the cardiac conduction system requiring permanent pacemaker (PPM) implantation is a known adverse outcome of transcatheter aortic valve replacement (TAVR). A permanent-temporary pacemaker (PTPM) is a device that involves an active-fixation lead attached to an external pulse generator taped to the skin. We reviewed the utility of PTPMs as a temporary bridge measure after TAVR in patients with conduction abnormalities that do not meet conventional criteria for PPM placement.
Between January 01, 2013 and December 31, 2015, we analyzed 67 patients who received PTPM after TAVR. Baseline demographics, comorbidities, type and size of the valve, pre-TAVR electrocardiograms (ECGs), post-TAVR ECGs at 1 day, 1 month, and 6 months, and pacemaker interrogation results were reviewed for each patient if available.
The mean age of patients was 80.5 ± 9.1 years. PTPM were placed for 2.3 ± 2.4 days. Among these patients, 44.8% (n = 30) received a PPM prior to discharge. Male gender (OR 2.84, 95% CI 1.05-7.69, p = 0.05) and an increase in QRS duration post-TAVR (p = 0.01) were associated with PPM placement. Pacemaker interrogation data of 11 patients with PPM revealed that 27% (n = 3) had < 1% V-pacing requirements and < 10% A-pacing requirements.
In post-TAVR patients who develop conduction abnormalities that do not meet conventional PPM implantation indications, PTPM safely provides a time period for further assessment and may prevent unnecessary PPM implantation. Male gender and an increase in QRS duration post-TAVR are associated with PPM implantation. Additionally, some patients may recover from their conduction disturbances and demonstrate low pacemaker utilization.
需要植入永久起搏器(PPM)的心脏传导系统损伤是经导管主动脉瓣置换术(TAVR)已知的不良后果。永久-临时起搏器(PTPM)是一种将主动固定导线连接到贴在皮肤上的外部脉冲发生器的装置。我们回顾了PTPM作为TAVR后对不符合PPM植入常规标准的传导异常患者的临时过渡措施的效用。
在2013年1月1日至2015年12月31日期间,我们分析了67例TAVR后接受PTPM的患者。若有数据,对每位患者的基线人口统计学、合并症、瓣膜类型和尺寸、TAVR前心电图(ECG)、TAVR后1天、1个月和6个月的ECG以及起搏器程控结果进行了回顾。
患者的平均年龄为80.5±9.1岁。PTPM放置时间为2.3±2.4天。在这些患者中,44.8%(n = 30)在出院前接受了PPM。男性(OR 2.84,95%CI 1.05 - 7.69,p = 0.05)和TAVR后QRS时限增加(p = 0.01)与PPM植入相关。11例接受PPM患者的起搏器程控数据显示,27%(n = 3)的患者心室起搏需求<1%,心房起搏需求<10%。
在TAVR后出现不符合常规PPM植入指征的传导异常的患者中,PTPM安全地提供了进一步评估的时间段,并可能防止不必要的PPM植入。男性和TAVR后QRS时限增加与PPM植入相关。此外,一些患者可能从传导障碍中恢复,并显示起搏器使用率较低。