Hippo-Yap信号通路在眼部发育和疾病中的作用
Hippo-yap signaling in ocular development and disease.
作者信息
Lee Matthew, Goraya Navneet, Kim Seonhee, Cho Seo-Hee
机构信息
Shriners Hospitals Pediatric Research Center and Department of Anatomy and Cell Biology, Temple University Lewis Katz School of Medicine, Philadelphia, Pennsylvania.
出版信息
Dev Dyn. 2018 Jun;247(6):794-806. doi: 10.1002/dvdy.24628. Epub 2018 Apr 23.
The Hippo-Yes associated protein (Yap) pathway plays an important role in organ size control by regulating cell proliferation, apoptosis, and stem cell renewal. Hippo-Yap signaling also functions at the level of cellular development in a variety of organs through its effects on cell cycle control, cell survival, cell polarity, and cell fate. Because of its important roles in normal development and homeostasis, abnormal regulation of this pathway has been shown to lead to pathological outcomes such as tissue overgrowth, tumor formation, and abnormal organogenesis, including ocular-specific disorders. In this review, we summarize how normal and perturbed control of Yap signaling is implicated in ocular development and disease Developmental Dynamics 247:794-806, 2018. © 2018 Wiley Periodicals, Inc.
河马-Yes相关蛋白（Yap）信号通路通过调节细胞增殖、凋亡和干细胞更新，在器官大小控制中发挥重要作用。河马-Yap信号传导还通过对细胞周期控制、细胞存活、细胞极性和细胞命运的影响，在多种器官的细胞发育水平上发挥作用。由于其在正常发育和体内平衡中的重要作用，该信号通路的异常调节已被证明会导致病理结果，如组织过度生长、肿瘤形成和包括眼部特异性疾病在内的异常器官发生。在这篇综述中，我们总结了Yap信号的正常和扰动控制如何与眼部发育和疾病相关。《发育动力学》247:794 - 806, 2018。© 2018威利期刊公司。
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