Department of Clinical and Experimental Medicine, University of Pisa, I‑56126 Pisa, Italy.
Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, I‑56126 Pisa, Italy.
Mol Med Rep. 2018 May;17(5):6914-6918. doi: 10.3892/mmr.2018.8712. Epub 2018 Mar 9.
Vanadium is a soft, silvery‑grey metal with a number of different oxidation states. The most common commercial form of vanadium is vanadium pentoxide (V2O5). All vanadium compounds are considered toxic. An increase in skin rashes has been observed in certain vanadium workers, including the development of atopic dermatitis. However, to the best of our knowledge, no prior in vivo or in vitro studies have evaluated the effect of vanadium exposure in human dermal fibroblasts. The present study evaluated the effect of V2O5 on proliferation and chemokine secretion in dermal fibroblasts. The results revealed that V2O5 had no significant effect on the viability or proliferation of fibroblasts, however it was able to induce the secretion of T‑helper (Th)1 chemokines from dermal fibroblasts, synergistically increasing the effect of important Th1 cytokines, including interferon‑γ and tumor necrosis factor‑α. Through these processes, V2O5 may lead to the induction and perpetuation of an inflammatory reaction in dermal tissue. The induction and perpetuation of inflammation in the dermis and the variety of involved candidate genes may be at the base of V2O5‑induced effects following occupational and environmental exposures. Further studies are necessary to evaluate dermal integrity and manifestations in subjects who are occupationally exposed, or living in polluted areas.
钒是一种软质、银灰色的金属，具有多种不同的氧化态。最常见的商业形式的钒是五氧化二钒(V2O5)。所有的钒化合物都被认为是有毒的。在某些钒作业工人中观察到皮肤疹增加，包括特应性皮炎的发生。然而，据我们所知，以前没有研究评估过钒暴露对人真皮成纤维细胞的影响。本研究评估了 V2O5 对真皮成纤维细胞增殖和趋化因子分泌的影响。结果表明，V2O5 对成纤维细胞的活力或增殖没有显著影响，但它能够诱导真皮成纤维细胞分泌 Th1 趋化因子，协同增强重要 Th1 细胞因子的作用，包括干扰素-γ和肿瘤坏死因子-α。通过这些过程，V2O5 可能导致真皮组织中炎症反应的诱导和持续。真皮中的炎症诱导和持续以及涉及的候选基因的多样性可能是职业和环境暴露后 V2O5 诱导作用的基础。有必要进一步研究评估职业暴露或生活在污染地区的受试者的皮肤完整性和表现。
