Institute for Mental Health, School of Psychology, University of Birmingham, Birmingham, UK.
Institute for Mental Health, School of Psychology and Institute of Clinical Sciences, University of Birmingham, Birmingham, UK.
Acta Psychiatr Scand. 2018 May;137(5):380-390. doi: 10.1111/acps.12873. Epub 2018 Mar 13.
To provide an update on the evidence base for the nature of the relationship between negative symptoms and depressive features in people with schizophrenia, and propose new models that reflect their complex relationship.
A systematic review following PRISMA guidelines. A total of 2210 articles were identified from EMBASE, PsychInfo and MEDLINE, and further two articles were hand-searched from references. Twenty-seven met inclusion criteria and were included in the review.
In schizophrenia, primary evidence suggests symptoms of low mood, suicidal ideation and pessimism have more specificity for depression whereas alogia and blunted affect may have more specificity as negative symptoms. Anhedonia, anergia and avolition may be common to both.
It may be possible to further distinguish depressive features from negative symptoms in schizophrenia when detailed phenomenology is considered. However, in a proposed dimensional model, these two domains continue to share certain phenomena, highlighting their close relationship.
提供有关精神分裂症患者阴性症状和抑郁特征之间关系本质的证据基础的最新信息，并提出反映其复杂关系的新模型。
按照 PRISMA 指南进行系统评价。从 EMBASE、PsychInfo 和 MEDLINE 中确定了 2210 篇文章，并从参考文献中进一步手动搜索了两篇文章。符合纳入标准的有 27 篇，纳入了综述。
在精神分裂症中，主要证据表明，情绪低落、自杀意念和悲观情绪等症状对抑郁症具有更高的特异性，而言语贫乏和情感迟钝则可能对阴性症状具有更高的特异性。快感缺失、乏力和意志缺乏可能两者都有。
当考虑详细的现象学时，可能有可能进一步区分精神分裂症中的抑郁特征和阴性症状。然而，在一个提出的维度模型中，这两个领域继续共享某些现象，突出了它们的密切关系。
