Walsh-Monteiro A, Morato S, Uribe F A R, Gouveia A, Pedroso J S
Laboratório de Neuroquímica e Comportamento, Coordenação de Ciências Biológicas, Campus Tucuruí, Instituto Federal do Pará, Tucuruí, PA, Brasil.
Laboratório de Comportamento Exploratório, Faculdade de Filosofia, Ciências e Letras, Universidade de São Paulo, Ribeirão Preto, SP, Brasil.
Braz J Med Biol Res. 2025 Aug 29;58:e14687. doi: 10.1590/1414-431X2025e14687. eCollection 2025.
This systematic review investigates the effects of the ayahuasca beverage (Aya) in various animal models. Using the PRISMA protocol and adhering to the Cochrane Handbook for Systematic Reviews, a comprehensive selection of 2,359 documents was identified from the Web of Science, Medline, and Scopus databases between 2012 and 2022. Following the inclusion and exclusion criteria, 14 articles were included in the final analysis. The analysis revealed a diversity in the selection of animal models that included different developmental stages and various forms of Aya intoxication, including acute and chronic doses, and varying concentrations of the active principles. The studies revealed that Aya causes significant alterations in the motor and cognitive behavior of animals, especially associated with the serotonergic system, which seems to contribute to the negative symptoms also observed in schizophrenia and depression. Despite the evidence found, this review highlights the scarcity of more robust pre-clinical studies with methodological standardization to make more conclusive comparisons, especially given the need to identify potential toxic and neurochemical effects of Aya on organisms for a safer assessment of its therapeutic use.
本系统评价研究了死藤水饮料（Aya）在各种动物模型中的作用。采用PRISMA方案并遵循Cochrane系统评价手册，从2012年至2022年期间的Web of Science、Medline和Scopus数据库中全面筛选出2359篇文献。按照纳入和排除标准，最终分析纳入了14篇文章。分析发现动物模型的选择存在多样性，包括不同的发育阶段以及各种形式的Aya中毒，如急性和慢性剂量以及不同浓度的活性成分。研究表明，Aya会导致动物的运动和认知行为发生显著改变，尤其是与血清素能系统相关，这似乎也导致了在精神分裂症和抑郁症中观察到的阴性症状。尽管有这些发现，但本评价强调缺乏更多方法标准化的有力临床前研究，以便进行更具结论性的比较，特别是鉴于需要确定Aya对生物体的潜在毒性和神经化学作用，以更安全地评估其治疗用途。
