Porazinski Sean, Ladomery Michael
Faculty of Health and Applied Sciences, University of the West of England, Frenchay Campus, Bristol BS16 1QY, UK.
Genes (Basel). 2018 Mar 13;9(3):161. doi: 10.3390/genes9030161.
Alternative splicing is a well-studied gene regulatory mechanism that produces biological diversity by allowing the production of multiple protein isoforms from a single gene. An involvement of alternative splicing in the key biological signalling Hippo pathway is emerging and offers new therapeutic avenues. This review discusses examples of alternative splicing in the Hippo pathway, how deregulation of these processes may contribute to disease and whether these processes offer new potential therapeutic targets.
可变剪接是一种经过充分研究的基因调控机制，它通过允许从单个基因产生多种蛋白质异构体来产生生物多样性。可变剪接在关键的生物信号通路——Hippo通路中的作用正在显现，并提供了新的治疗途径。本文综述了Hippo通路中可变剪接的实例，这些过程的失调如何导致疾病，以及这些过程是否提供了新的潜在治疗靶点。
