Takeuchi T, Schlossman S F, Morimoto C
Cell Immunol. 1987 Jun;107(1):107-14. doi: 10.1016/0008-8749(87)90270-x.
It is suggested that autologous mixed lymphocyte reaction (AMLR) may play an important role in generating suppressor inducer signals and in down-regulating the immune response following self-major histocompatibility recognition. In the present study, monoclonal antibodies directed at cell surface structures on T4+ cells activated in AMLR were used to define the molecules important in the generation of the suppressor inducer signal. The density of a 200/220-kDa structure, termed 2H4, increased on T4 cells during activation in AMLR and furthermore a strong correlation was observed between the generated suppressor inducer activity of such cells and the density of the 2H4 antigen. More importantly, we showed that treatment of AMLR activated T4 cells with anti-2H4 but not anti-T3 or T4 antibody abolished the suppressor inducer function of these cells. These results suggest that the 2H4 molecule but not the T3-receptor complex plays an important role in generating suppressor inducer signals in the AMLR system.
有人提出，自体混合淋巴细胞反应（AMLR）可能在产生抑制诱导信号以及在自身主要组织相容性识别后下调免疫反应中发挥重要作用。在本研究中，针对在AMLR中活化的T4 +细胞表面结构的单克隆抗体被用于确定在抑制诱导信号产生中起重要作用的分子。一种称为2H4的200/220-kDa结构的密度在AMLR活化过程中在T4细胞上增加，此外，观察到此类细胞产生的抑制诱导活性与2H4抗原的密度之间存在强烈相关性。更重要的是，我们表明用抗2H4而不是抗T3或T4抗体处理AMLR活化的T4细胞消除了这些细胞的抑制诱导功能。这些结果表明，2H4分子而非T3受体复合物在AMLR系统中产生抑制诱导信号中起重要作用。
