青少年类风湿关节炎患者自体混合淋巴细胞反应中白细胞介素-2的产生
IL-2 production in the autologous mixed lymphocyte reaction of patients with juvenile rheumatoid arthritis.
作者信息
Oen K, Warrington R, Rosenberg A M, Krzekotowska D
机构信息
Department of Pediatrics, University of Manitoba, Winnipeg, Saskatchewan.
出版信息
Clin Exp Immunol. 1988 Oct;74(1):87-93.
Interleukin 2 (IL-2) production in the CD4/non-T cell autologous mixed lymphocyte reaction (AMLR) was estimated for patients with juvenile rheumatoid arthritis (JRA). A cellular IL-2 assay (CILA) consisting of co-cultures of indicator cells, CTLL-2, added to CD4/non-T cell AMLR cultures was used. As both CD4 and CTLL-2 cell proliferation are IL-2 dependent, results of the CILA assay were taken as a reflection of the total IL-2 in the co-culture. By this assay most patients with JRA had normal IL-2 production. However, five patients with polyarticular disease had both a low AMLR and low levels of IL-2 production. Three of those tested showed little improvement in the AMLR on addition of recombinant IL-2, suggesting decreased responsiveness to IL-2 as well.
对青少年类风湿性关节炎（JRA）患者，评估了其在CD4/非T细胞自体混合淋巴细胞反应（AMLR）中白细胞介素2（IL-2）的产生情况。采用了一种细胞IL-2检测法（CILA），即将指示细胞CTLL-2与CD4/非T细胞AMLR培养物共培养。由于CD4和CTLL-2细胞增殖均依赖IL-2，CILA检测结果被视为共培养中总IL-2的反映。通过该检测，大多数JRA患者的IL-2产生正常。然而，五名多关节疾病患者的AMLR及IL-2产生水平均较低。其中三名接受检测的患者在添加重组IL-2后，AMLR几乎没有改善，这表明对IL-2的反应性也降低。
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