Cheah Menghon, Andrews Melissa R
John van Geest Centre for Brain Repair, University of Cambridge, Cambridge CB2 0PY, UK.
Centre for Developmental Neurobiology, King's College London, London SE1 1UL, UK.
Cells. 2018 Mar 10;7(3):20. doi: 10.3390/cells7030020.
Integrin activation is essential for creating functional transmembrane receptors capable of inducing downstream cellular effects such as cell migration, cell spreading, neurite outgrowth and axon regeneration. Integrins are bidirectional signalling molecules that mediate their effects by 'inside-out' and 'outside-in' signalling. This review will provide a detailed overview of integrin activation focusing on intracellular activation in neurons and discussing direct implications in the regulation of neurite outgrowth and axon regeneration.
整合素激活对于创建能够诱导下游细胞效应（如细胞迁移、细胞铺展、神经突生长和轴突再生）的功能性跨膜受体至关重要。整合素是双向信号分子，通过“由内向外”和“由外向内”信号传导介导其效应。本综述将详细概述整合素激活，重点关注神经元中的细胞内激活，并讨论其对神经突生长和轴突再生调节的直接影响。
