Innovative Green Product synthesis and Renewable Environment Development Research Group, Faculty of Environment and Labour Safety, Ton Duc Thang University, Ho Chi Minh City, Viet Nam.
School of Chemical Engineering, Yeungnam University, Gyeongsan, Gyeongbuk 38541, Republic of Korea.
Life Sci. 2018 May 1;200:26-30. doi: 10.1016/j.lfs.2018.03.023. Epub 2018 Mar 10.
Doxorubicin (Dox) is a valuable anticancer drug for hematologic and solid tumors. Yet, it can cause multi-organ toxicities in various patients. Since toxicity evaluation is a major criterion to discuss for every experiment, the current mini-review focuses on the toxicity of Dox to multiple organs and suggests the most probable mechanism. Though several mechanisms have been suggested, the role of oxidative stress remains elusive among other mechanisms and remains the most probable mechanism for cardiotoxic effect of Dox.
多柔比星（Dox）是一种用于血液系统肿瘤和实体瘤的有价值的抗癌药物。然而，它会导致不同患者出现多器官毒性。由于毒性评估是每个实验都需要讨论的主要标准，因此当前的小型综述重点关注 Dox 对多个器官的毒性，并提出了最可能的机制。尽管已经提出了几种机制，但氧化应激的作用在其他机制中仍然难以捉摸，并且仍然是 Dox 心脏毒性的最可能机制。
