Maudgal P C, De Clercq E, Huyghe P
Curr Eye Res. 1987 Apr;6(4):579-84. doi: 10.3109/02713688709025216.
Trifluridine (TFT) and a structurally related analogue, 5-fluoro-2'-deoxyuridine (FDU), were investigated for their efficacy in the topical treatment of experimental keratitis caused by thymidine kinase-positive (TK+) and thymidine kinase-deficient (TK-) herpes simplex virus type 1 (HSV-1) strains. Bromovinyldeoxyuridine (BVDU) was used as a reference compound. Both 0.2% BVDU and 0.2% TFT eyedrops produced a highly significant healing of TK+HSV-1 keratitis as compared to the placebo and 0.2% FDU eyedrops (P much less than 0.005), whereas the latter compound did not differ from placebo eyedrops. In the treatment of TK HSV-1 keratitis, none of the drugs exhibited a beneficial healing effect, although the virus strain used was inhibited in vitro by TFT and FDU at a very low concentration (0.02-0.04 microgram/mL).
研究了曲氟尿苷（TFT）及其结构相关类似物5-氟-2'-脱氧尿苷（FDU）对由胸苷激酶阳性（TK +）和胸苷激酶缺陷（TK -）的1型单纯疱疹病毒（HSV-1）毒株引起的实验性角膜炎的局部治疗效果。溴乙烯基脱氧尿苷（BVDU）用作参考化合物。与安慰剂和0.2% FDU滴眼液相比，0.2% BVDU和0.2% TFT滴眼液均使TK + HSV-1角膜炎得到了高度显著的愈合（P远小于0.005），而后者与安慰剂滴眼液无差异。在治疗TK - HSV-1角膜炎时，尽管所用病毒毒株在体外被TFT和FDU以非常低的浓度（0.02 - 0.04微克/毫升）抑制，但没有一种药物表现出有益的愈合效果。
