溴乙烯脱氧尿苷（BVDU）和三氟胸苷（TFT）治疗树枝状角膜溃疡的随机双盲试验
Randomised double-blind trial of bromovinyldeoxyuridine (BVDU) and trifluorothymidine (TFT) in dendritic corneal ulceration.
作者信息
Power W J, Benedict-Smith A, Hillery M, Brady K, Collum L M
机构信息
Professorial Unit, Royal Victoria Eye and Ear Hospital, Dublin, Ireland.
出版信息
Br J Ophthalmol. 1991 Nov;75(11):649-51. doi: 10.1136/bjo.75.11.649.
Abstract
The results of a randomised double-blind clinical trial of 0.1% bromovinyldeoxyuridine (BVDU) and 1% trifluorothymidine (TFT) in 60 patients with corneal dendritic ulceration are presented. There was no significant difference between BVDU and TFT in terms of numbers of ulcers healed (p = 0.61), mean healing time (p = 0.065), and cumulative healing rate (p = 0.058). No serious side effects were observed, though transient stinging was recorded in five patients receiving TFT and in three patients receiving BVDU. One patient in the group treated with TFT developed a punctate epitheliopathy.
摘要
本文介绍了一项针对60例角膜树枝状溃疡患者的随机双盲临床试验结果，该试验比较了0.1%溴乙烯脱氧尿苷（BVDU）和1%三氟胸苷（TFT）的疗效。在溃疡愈合数量（p = 0.61）、平均愈合时间（p = 0.065）和累积愈合率（p = 0.058）方面，BVDU和TFT之间没有显著差异。未观察到严重副作用，不过有5例接受TFT治疗的患者和3例接受BVDU治疗的患者记录到短暂刺痛。接受TFT治疗的组中有1例患者发生点状上皮病变。
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