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Randomised double-blind trial of bromovinyldeoxyuridine (BVDU) and trifluorothymidine (TFT) in dendritic corneal ulceration.溴乙烯脱氧尿苷（BVDU）和三氟胸苷（TFT）治疗树枝状角膜溃疡的随机双盲试验
Br J Ophthalmol. 1991 Nov;75(11):649-51. doi: 10.1136/bjo.75.11.649.
2
Bromovinyldeoxyuridine (BVDU) and trifluorothymidine (TFT) in dendritic corneal ulceration: a double blind controlled study.溴乙烯基脱氧尿苷（BVDU）和三氟胸苷（TFT）治疗树枝状角膜溃疡的双盲对照研究。
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Experimental stroma herpes simplex keratitis. Influence of treatment with topical bromovinyldeoxyuridine and trifluridine.实验性基质型单纯疱疹性角膜炎。局部应用溴乙烯脱氧尿苷和三氟尿苷治疗的影响。
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本文引用的文献

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(E)-5-(2-bromovinyl)-2'-Deoxyuridine in the treatment of experimental herpes simplex keratitis.（E）-5-（2-溴乙烯基）-2'-脱氧尿苷治疗实验性单纯疱疹性角膜炎
Antimicrob Agents Chemother. 1980 Jan;17(1):8-12. doi: 10.1128/AAC.17.1.8.
2
Efficacy of (E)-5-(2-bromovinyl)-2'-deoxyuridine in the topical treatment of herpes simplex keratitis.（E）-5-（2-溴乙烯基）-2'-脱氧尿苷局部治疗单纯疱疹性角膜炎的疗效
Albrecht Von Graefes Arch Klin Exp Ophthalmol. 1981;216(4):261-8. doi: 10.1007/BF00455033.
3
Randomised double-blind trial of acyclovir and idoxuridine in dendritic corneal ulceration.阿昔洛韦与碘苷治疗树枝状角膜溃疡的随机双盲试验。
Br J Ophthalmol. 1980 Oct;64(10):766-9. doi: 10.1136/bjo.64.10.766.
4
Experimental stroma herpes simplex keratitis. Influence of treatment with topical bromovinyldeoxyuridine and trifluridine.实验性基质型单纯疱疹性角膜炎。局部应用溴乙烯脱氧尿苷和三氟尿苷治疗的影响。
Arch Ophthalmol. 1982 Apr;100(4):653-6. doi: 10.1001/archopht.1982.01030030655027.
5
Acyclovir (Zovirax) in herpetic disciform keratitis.阿昔洛韦（无环鸟苷）治疗盘状疱疹性角膜炎。
Br J Ophthalmol. 1983 Feb;67(2):115-8. doi: 10.1136/bjo.67.2.115.
6
On the mechanism of selective inhibition of herpesvirus replication by (E)-5-(2-bromovinyl)-2'-deoxyuridine.关于（E）-5-（2-溴乙烯基）-2'-脱氧尿苷对疱疹病毒复制的选择性抑制机制
Proc Natl Acad Sci U S A. 1981 May;78(5):2698-702. doi: 10.1073/pnas.78.5.2698.
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Specific phosphorylation of E-5-(2-iodovinyl)-2'-deoxyuridine by herpes simplex virus-infected cells.
J Biol Chem. 1981 Jun 25;256(12):5973-6.
8
Clinical evaluation of trifluorothymidine in the treatment of herpes simplex corneal ulcers.三氟胸苷治疗单纯疱疹性角膜溃疡的临床评估
Am J Ophthalmol. 1972 Jun;73(6):932-42. doi: 10.1016/0002-9394(72)90463-1.
9
Oral acyclovir (Zovirax) in herpes simplex dendritic corneal ulceration.口服阿昔洛韦（无环鸟苷）治疗单纯疱疹性树枝状角膜溃疡
Br J Ophthalmol. 1986 Jun;70(6):435-8. doi: 10.1136/bjo.70.6.435.
10
Bromovinyldeoxyuridine and interferon treatment in ulcerative herpetic keratitis: a double masked study.溴乙烯基脱氧尿苷与干扰素治疗溃疡性疱疹性角膜炎：一项双盲研究。
Br J Ophthalmol. 1989 Aug;73(8):604-7. doi: 10.1136/bjo.73.8.604.

溴乙烯脱氧尿苷（BVDU）和三氟胸苷（TFT）治疗树枝状角膜溃疡的随机双盲试验

Randomised double-blind trial of bromovinyldeoxyuridine (BVDU) and trifluorothymidine (TFT) in dendritic corneal ulceration.

作者信息

Power W J, Benedict-Smith A, Hillery M, Brady K, Collum L M

机构信息

Professorial Unit, Royal Victoria Eye and Ear Hospital, Dublin, Ireland.

出版信息

Br J Ophthalmol. 1991 Nov;75(11):649-51. doi: 10.1136/bjo.75.11.649.

DOI:10.1136/bjo.75.11.649
PMID:1751456
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1042518/
Abstract

The results of a randomised double-blind clinical trial of 0.1% bromovinyldeoxyuridine (BVDU) and 1% trifluorothymidine (TFT) in 60 patients with corneal dendritic ulceration are presented. There was no significant difference between BVDU and TFT in terms of numbers of ulcers healed (p = 0.61), mean healing time (p = 0.065), and cumulative healing rate (p = 0.058). No serious side effects were observed, though transient stinging was recorded in five patients receiving TFT and in three patients receiving BVDU. One patient in the group treated with TFT developed a punctate epitheliopathy.

摘要

本文介绍了一项针对60例角膜树枝状溃疡患者的随机双盲临床试验结果，该试验比较了0.1%溴乙烯脱氧尿苷（BVDU）和1%三氟胸苷（TFT）的疗效。在溃疡愈合数量（p = 0.61）、平均愈合时间（p = 0.065）和累积愈合率（p = 0.058）方面，BVDU和TFT之间没有显著差异。未观察到严重副作用，不过有5例接受TFT治疗的患者和3例接受BVDU治疗的患者记录到短暂刺痛。接受TFT治疗的组中有1例患者发生点状上皮病变。