Battal Merlet Lâle, Blanchet Alain, Lockman Hazlin, Kostova Milena
Université Paris Lumières, Université Paris 8, Laboratoire de Psychopathologie et Neuropsychologie, EA 2027, Saint-Denis, France.
Psychological Medicine Department, University Malaya, Kuala Lumpur, Malaysia.
Schizophr Res Treatment. 2018 Jan 1;2018:8501973. doi: 10.1155/2018/8501973. eCollection 2018.
The objective of this electrophysiological study was to investigate the processing of semantic coherence during encoding in relation to episodic memory processes promoted at test, in schizophrenia patients, by using the N400 paradigm. Eighteen schizophrenia patients and 15 healthy participants undertook a recognition memory task. The stimuli consisted of pairs of words either semantically related or unrelated to a given category name (context). During encoding, both groups exhibited an N400 external semantic coherence effect. Healthy controls also showed an N400 internal semantic coherence effect, but this effect was not present in patients. At test, related stimuli were accompanied by an FN400 old/new effect in both groups and by a parietal old/new effect in the control group alone. In the patient group, external semantic coherence effect was associated with FN400, while, in the control group, it was correlated to the parietal old/new effect. Our results indicate that schizophrenia patients can process the contextual information at encoding to enhance familiarity process for related stimuli at test. Therefore, cognitive rehabilitation therapies targeting the implementation of semantic encoding strategies can mobilize familiarity which in turn can overcome the recollection deficit, promoting successful episodic memory performance in schizophrenia patients.
这项电生理研究的目的是，通过使用N400范式，调查精神分裂症患者在编码过程中语义连贯的处理情况，以及与测试时促进的情景记忆过程之间的关系。18名精神分裂症患者和15名健康参与者进行了一项识别记忆任务。刺激物由与给定类别名称（上下文）语义相关或不相关的单词对组成。在编码过程中，两组均表现出N400外部语义连贯效应。健康对照组还表现出N400内部语义连贯效应，但患者组未出现此效应。在测试时，相关刺激在两组中均伴有FN400新旧效应，而仅在对照组中伴有顶叶新旧效应。在患者组中，外部语义连贯效应与FN400相关，而在对照组中，它与顶叶新旧效应相关。我们的结果表明，精神分裂症患者在编码时能够处理上下文信息，以增强测试时对相关刺激的熟悉程度。因此，针对语义编码策略实施的认知康复疗法可以调动熟悉度，进而克服回忆缺陷，促进精神分裂症患者情景记忆的成功表现。
