Jiang Jung-Rern, Yen Shiao-Yu, Chiang Pei-Fu, Liu Hsiao-Chien
Department of Internal Medicine, St. Joseph's Hospital, #74 Sinsheng Rd, Huwei, 632, Yunlin County, Taiwan.
Department of Health Protection, Public Health Bureau, No. 34 Fuwen Rd, Douliu, 64054, Yunlin County, Taiwan.
J Anesth. 2018 Jun;32(3):351-359. doi: 10.1007/s00540-018-2482-z. Epub 2018 Mar 13.
This study analyzed the clinical factors with the aim to determine the relationship between endotracheal tube (ETT) size and leakage ventilation (LV) and tracheal dilatation.
All patients with ETT intubation and ventilator support for more than 6 months were retrospectively evaluated. The inner tracheal diameter (TD) was measured over image at the starting and 6 months after ventilator initiated. We compared the clinical factors, outcomes and complications between patients with and without LV, as well as with and without a TD enlarging more than 25% after 6 months (TDn). Logistic regression analyses of factors related to the LV and TDn were performed. The cut-off points of the ratio of outer diameter of ETT (OD) to TD were set and evaluated for their accuracy of predicting LV and TDn.
689 patients were enrolled initially and eventually 199 patients were included, of which 52 and 66 patients were identified to have LV and TDn, respectively. Patients with LV had a higher peak inspiratory pressure (PIP), smaller initial ETT OD/TD and higher incidence of pneumonia. Patients with TDn had a higher PIP, larger initial OD/TD and higher incidence of pneumonia. A higher PIP and smaller initial OD/TD were significantly related to LV and a higher PIP and larger initial OD/TD were significantly related to TDn. The incidence of LV and TDn was higher in patients with an initial OD/TD less than 0.51 and more than 0.54, respectively.
The initial ETT OD/TD ratio is a predictor for LV and TDn.
本研究分析临床因素,旨在确定气管内插管(ETT)尺寸与漏气通气(LV)及气管扩张之间的关系。
对所有接受ETT插管并使用呼吸机支持超过6个月的患者进行回顾性评估。在呼吸机启动时及启动6个月后通过影像测量气管内径(TD)。我们比较了有和无LV患者以及6个月后TD增大超过25%(TDn)和未增大患者之间的临床因素、结局及并发症。对与LV和TDn相关的因素进行逻辑回归分析。设定ETT外径(OD)与TD比值的截断点,并评估其预测LV和TDn的准确性。
最初纳入689例患者,最终纳入199例,其中分别有52例和66例患者被确定存在LV和TDn。有LV的患者吸气峰压(PIP)更高、初始ETT OD/TD更小且肺炎发生率更高。有TDn的患者PIP更高、初始OD/TD更大且肺炎发生率更高。较高的PIP和较小的初始OD/TD与LV显著相关,较高的PIP和较大的初始OD/TD与TDn显著相关。初始OD/TD小于0.51和大于0.54的患者中,LV和TDn的发生率分别更高。
初始ETT OD/TD比值是LV和TDn的预测指标。