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[气管支气管软化症]

[Tracheobronchomalacia].

作者信息

Majid Adnan, Fernández Liliana, Fernández-Bussy Sebastián, Herth Felix, Ernst Armin

机构信息

División de Neumología Intervencionista, Beth Israel Deaconess Medical Center, Boston, MA, USA.

出版信息

Arch Bronconeumol. 2010 Apr;46(4):196-202. doi: 10.1016/j.arbres.2009.10.011. Epub 2009 Dec 9.

Abstract

Tracheobronchomalacia is a central airway disease characterised by weakness of the wall and dynamic decrease in the tracheal lumen and the large bronchi, particularly while exhaling. It is more common in middle age and the elderly with previous exposure to cigarettes. It causes chronic symptoms such as cough, dyspnea, increase in recurrent infections, and poor secretion management, but it can also progress to chronic respiratory failure and death. It is usually confused with other common diseases like chronic obstructive pulmonary disease (COPD) or asthma. Its causes can be congenital or acquired and its diagnosis involves the dynamic assessment of the airway with tomography and fibrobronchoscopy. It is classified as mild, moderate or severe depending on the degree of collapse of the airway when exhaling. Management consists of a primary phase, in which concomitant diseases must be controlled, such as COPD, asthma or gastro-oesophageal reflux. In diffuse moderate to severe symptomatic tracheobronchomalacia tracheobronchoplasty must be considered with strengthening of the posterior wall. Silicone and "Y" stents can be used to identify patients who could potentially benefit from surgical treatment as well as being used for the definitive symptomatic treatment with high surgical risk. More prospective studies need to be done in order to standardise certain common criteria for the management of this usually under-diagnosed disease.

摘要

气管支气管软化症是一种中央气道疾病,其特征是气管壁薄弱以及气管腔和大气道在呼气时动态变窄。在有吸烟史的中年人和老年人中更为常见。它会引发慢性症状,如咳嗽、呼吸困难、反复感染增加以及分泌物管理不佳等,还可能进展为慢性呼吸衰竭甚至死亡。它通常会与慢性阻塞性肺疾病(COPD)或哮喘等其他常见疾病相混淆。其病因可能是先天性的,也可能是后天获得的,诊断需要通过断层扫描和纤维支气管镜对气道进行动态评估。根据呼气时气道塌陷的程度,可将其分为轻度、中度或重度。治疗包括第一阶段,即必须控制诸如COPD、哮喘或胃食管反流等伴随疾病。对于弥漫性中度至重度症状性气管支气管软化症,必须考虑进行气管支气管成形术并加强后壁。硅胶和“Y”形支架可用于确定可能从手术治疗中获益的患者,也可用于具有高手术风险的确定性对症治疗。需要开展更多前瞻性研究,以便为这种通常诊断不足的疾病的治疗规范某些通用标准。

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