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本文引用的文献

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KDM4A regulates HIF-1 levels through H3K9me3.KDM4A 通过 H3K9me3 调节 HIF-1 水平。
Sci Rep. 2017 Sep 11;7(1):11094. doi: 10.1038/s41598-017-11658-3.
2
Maternal expression of the histone demethylase Kdm4a is crucial for pre-implantation development.组蛋白去甲基化酶Kdm4a的母体表达对植入前发育至关重要。
Development. 2017 Sep 15;144(18):3264-3277. doi: 10.1242/dev.155473. Epub 2017 Aug 21.
3
Defining the Role of Estrogen Receptor β in the Regulation of Female Fertility.确定雌激素受体β在女性生育调节中的作用。
Endocrinology. 2017 Jul 1;158(7):2330-2343. doi: 10.1210/en.2016-1916.
4
The role of ovarian reserve markers in prediction of clinical pregnancy.卵巢储备标志物在预测临床妊娠中的作用。
J Obstet Gynaecol. 2017 May;37(4):492-497. doi: 10.1080/01443615.2016.1269730. Epub 2017 Feb 17.
5
Specific ranges of anti-Mullerian hormone and antral follicle count correlate to provide a prognostic indicator for IVF outcome.抗苗勒管激素的特定范围与窦卵泡计数相关，可为体外受精结果提供预后指标。
Reprod Biol. 2017 Mar;17(1):51-59. doi: 10.1016/j.repbio.2016.12.002. Epub 2017 Jan 26.
6
The effect of serum and follicular fluid anti-Mullerian hormone level on the number of oocytes retrieved and rate of fertilization and clinical pregnancy.血清和卵泡液抗苗勒管激素水平对获卵数、受精率及临床妊娠率的影响。
North Clin Istanb. 2016 Nov 25;3(2):90-96. doi: 10.14744/nci.2016.02418. eCollection 2016.
7
The histone demethylase KDM4B regulates peritoneal seeding of ovarian cancer.组蛋白去甲基化酶KDM4B调控卵巢癌的腹膜种植。
Oncogene. 2017 May 4;36(18):2565-2576. doi: 10.1038/onc.2016.412. Epub 2016 Nov 21.
8
Epigenetic Changes of the Cyp11a1 Promoter Region in Granulosa Cells Undergoing Luteinization During Ovulation in Female Rats.雌性大鼠排卵期间黄体化颗粒细胞中Cyp11a1启动子区域的表观遗传变化
Endocrinology. 2016 Sep;157(9):3344-54. doi: 10.1210/en.2016-1264. Epub 2016 Jul 18.
9
Epigenetic modification of long interspersed elements-1 in cumulus cells of mature and immature oocytes from patients with polycystic ovary syndrome.多囊卵巢综合征患者成熟和未成熟卵母细胞卵丘细胞中长散在核元件-1的表观遗传修饰
Clin Exp Reprod Med. 2016 Jun;43(2):82-9. doi: 10.5653/cerm.2016.43.2.82. Epub 2016 Jun 23.
10
Hypoxia-Inducible Histone Lysine Demethylases: Impact on the Aging Process and Age-Related Diseases.缺氧诱导型组蛋白赖氨酸去甲基化酶：对衰老过程及年龄相关疾病的影响
Aging Dis. 2016 Mar 15;7(2):180-200. doi: 10.14336/AD.2015.0929. eCollection 2016 Mar.

在体外受精过程中，卵丘颗粒细胞中组蛋白去甲基化酶 KDM4A 和 KDM4B 的表达。

Histone demethylase KDM4A and KDM4B expression in granulosa cells from women undergoing in vitro fertilization.

机构信息

Institute for Reproductive Health and Regenerative Medicine, Center for Reproductive Sciences, University of Kansas Medical Center, 3901 Rainbow Blvd. MS3050, Kansas City, KS, 66160, USA.

Department of Obstetrics and Gynecology, University of Kansas Medical Center, Kansas City, KS, 66160, USA.

出版信息

J Assist Reprod Genet. 2018 Jun;35(6):993-1003. doi: 10.1007/s10815-018-1151-3. Epub 2018 Mar 14.

DOI:10.1007/s10815-018-1151-3
PMID:29536385
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6029998/
Abstract

PURPOSE

To assess expression of the histone demethylases KDM4A and KDM4B in granulosa collected from women undergoing oocyte retrieval and to determine if expression was related to pregnancy outcome.

METHODS

Cumulus and mural granulosa cells were obtained from women undergoing oocyte retrieval. KDM4A and KDM4B mRNA expression was determined by qRT-PCR. KDM4A and KDM4B proteins were immunohistochemically localized in ovarian tissue sections obtained from archival specimens.

RESULTS

KDM4A and KDM4B protein was localized to oocytes, granulosa cells, and theca and luteal cells in ovaries from reproductive-aged women. KDM4A and KDM4B mRNA expression was overall higher in cumulus compared to mural granulosa. When comparing granulosa demethylase gene expression, KDM4A and KDM4B mRNA expression was higher in both cumulus and mural granulosa from not pregnant patients compared to patients in the pregnant-live birth group.

CONCLUSIONS

Histone demethylases KDM4A and KDM4B mRNA are differentially expressed in cumulus and mural granulosa. Expression of both KDM4A and KDM4B mRNA was lower in cumulus granulosa and mural granulosa from pregnant compared to not pregnant patients. These findings suggest that altered expression of histone demethylases may impact epigenetic changes in granulosa cells associated with pregnancy.

摘要

目的

评估组蛋白去甲基酶 KDM4A 和 KDM4B 在接受卵母细胞采集的女性的颗粒细胞中的表达，并确定其表达是否与妊娠结局有关。

方法

从接受卵母细胞采集的女性中获取卵丘和壁颗粒细胞。通过 qRT-PCR 测定 KDM4A 和 KDM4B mRNA 的表达。通过免疫组织化学定位在从存档标本获得的卵巢组织切片中定位 KDM4A 和 KDM4B 蛋白。

结果

KDM4A 和 KDM4B 蛋白定位于生殖年龄女性卵巢中的卵母细胞、颗粒细胞、膜和黄体细胞。与壁颗粒细胞相比，KDM4A 和 KDM4B mRNA 在卵丘中总体表达更高。比较颗粒细胞去甲基酶基因表达时，与妊娠活产组患者相比，未怀孕患者的卵丘和壁颗粒细胞中的 KDM4A 和 KDM4B mRNA 表达均更高。

结论

组蛋白去甲基酶 KDM4A 和 KDM4B mRNA 在卵丘和壁颗粒细胞中差异表达。与未怀孕患者相比，怀孕患者的卵丘颗粒细胞和壁颗粒细胞中的 KDM4A 和 KDM4B mRNA 表达均较低。这些发现表明，组蛋白去甲基酶的表达改变可能会影响与妊娠相关的颗粒细胞中的表观遗传变化。