Lindberg U B, Crona N, Enk L, Samsioe G, Silfverstolpe G
Horm Metab Res. 1987 May;19(5):222-5. doi: 10.1055/s-2007-1011783.
The effects of serum lipids and lipoproteins of 2 mg cyproterone acetate (CPA) given alone and in combination with 35 or 50 micrograms ethinyl estradiol (EE) were studied in 21 oophorectomized women in a study with a cross-over design. CPA in this low oral dose was rather inert in its effects on lipoprotein lipids. It induced only a small decrease in the free cholesterol and phospholipid content of the high density lipoprotein (HDL) fraction. As regards the CPA-EE combinations, they induced a slight increase in the HDL fraction, a small decrease in the low density lipoprotein (LDL) fraction and a substantial increase in triglycerides both in the serum and in the very low density lipoprotein (VLDL) fraction. This lipoprotein pattern is invariably induced after the administration of an alkylated estrogen or an "estrogen dominated" oral contraceptive. An increase in triglycerides is a "biochemical" adverse effect which may have clinical implications for some patients.
在一项采用交叉设计的研究中，对21名卵巢切除术后的女性进行了研究，观察单独给予2mg醋酸环丙孕酮（CPA）以及与35或50微克炔雌醇（EE）联合使用时对血清脂质和脂蛋白的影响。这种低口服剂量的CPA对脂蛋白脂质的影响相当不明显。它仅使高密度脂蛋白（HDL）部分的游离胆固醇和磷脂含量略有降低。至于CPA-EE组合，它们使HDL部分略有增加，低密度脂蛋白（LDL）部分略有降低，血清和极低密度脂蛋白（VLDL）部分的甘油三酯大幅增加。这种脂蛋白模式在给予烷基化雌激素或“雌激素为主”的口服避孕药后总是会出现。甘油三酯升高是一种“生化”不良反应，可能对某些患者有临床影响。
