Enk L, Crona N, Samsioe G, Silfverstolpe G
Horm Metab Res. 1986 Aug;18(8):551-4. doi: 10.1055/s-2007-1012371.
Non-alkylated estrogens, like estradiol valerate (F2V), are widely used in the treatment of the postmenopausal hormonal deficiency syndrome. Their effects on serum and lipoprotein lipids are characterized by an increase in the lipid constituents of high density lipoproteins (HDL) and, usually, a decrease in low density lipoproteins (LDL). These effects are considered beneficial as regards atherogenesis and the risk for cardiovascular diseases. Unlike the effects of alkylated estrogens, no concomitant increase in triglycerides (TG) in serum and very low density lipoproteins (VLDL) - adverse effects - are seen in doses of up to 2 mg E2V. In order to compare the effects of 2 and 4 mg of E2V on serum and lipoprotein lipids, 19 bilaterally oophorectomized women participated in a cross-over study after a 4 week long wash-out period. To evaluate the influence of the time factor, 10 of the women continued taking 2 mg and 9 taking 4 mg of E2V respectively for an additional period of 12 weeks, resulting in a total treatment period of 24 weeks per group. The serum lipoproteins were separated by preparative ultracentrifugation, the serum and lipoprotein lipids being assessed using commercially available kits. In the cross-over part of the study, total (TC) and free cholesterol (FC) and phospholipids (PL) increased in HDL and decreased in LDL. Neither dose increased TG in serum or VLDL. These changes in the lipoprotein pattern persisted at the end of the entire study. Consequently, within the range of commonly used doses (2 and 4 mg) E2V seems to have a constant and, in terms of cardiovascular disease, favourable influence on lipoprotein metabolism irrespective of doses and periods studied.
非烷基化雌激素，如戊酸雌二醇（F2V），广泛用于治疗绝经后激素缺乏综合征。它们对血清和脂蛋白脂质的影响表现为高密度脂蛋白（HDL）的脂质成分增加，通常低密度脂蛋白（LDL）减少。就动脉粥样硬化和心血管疾病风险而言，这些影响被认为是有益的。与烷基化雌激素的作用不同，在高达2mg戊酸雌二醇的剂量下，未观察到血清甘油三酯（TG）和极低密度脂蛋白（VLDL）同时增加——这是不良影响。为了比较2mg和4mg戊酸雌二醇对血清和脂蛋白脂质的影响，19名双侧卵巢切除的女性在经过4周的洗脱期后参加了一项交叉研究。为了评估时间因素的影响，其中10名女性继续分别服用2mg和9名服用4mg戊酸雌二醇，再持续12周，每组的总治疗期为24周。通过制备性超速离心分离血清脂蛋白，使用市售试剂盒评估血清和脂蛋白脂质。在研究的交叉部分，HDL中的总胆固醇（TC）、游离胆固醇（FC）和磷脂（PL）增加，LDL中的则减少。两种剂量均未增加血清或VLDL中的TG。脂蛋白模式的这些变化在整个研究结束时持续存在。因此，在常用剂量范围（2mg和4mg）内，戊酸雌二醇似乎对脂蛋白代谢具有持续且就心血管疾病而言有利的影响，无论所研究的剂量和疗程如何。
