Fux-Otta Carolina, Maliqueo Manuel, Echiburú Bárbara, Rosato Otilio, Crisosto Nicolás, Iraci Gabriel S, Fiol de Cuneo Marta, Szafryk de Mereshian Paula, Sir-Petermann Teresa
a Endocrinology and Diabetes Department, Faculty of Medical Sciences , Maternity and Neonatology University Hospital, National Córdoba University , Córdoba , Argentina.
b Faculty of Medical Sciences , Maternity and Neonatology University Hospital, University Institute for Reproductive Medicine (IUMER), National Córdoba University , Córdoba , Argentina.
J Obstet Gynaecol. 2018 Aug;38(6):750-755. doi: 10.1080/01443615.2017.1410532. Epub 2018 Mar 14.
Pregnancy complications and obstetric outcomes were compared in 80 Chilean (PPCOS) and 70 Argentinian (PPCOS) pregnant women. Reference groups of Chilean and Argentinian normal pregnant women from the same antenatal care units were also compared. PPCOS showed a higher prevalence of gestational diabetes mellitus (GDM) (OR, 2.28, 95% CI: 1.08-4.77, p = .030) and a lower prevalence of pregnancy-induced hypertension (PIH) (OR, 0.20, 95% CI: 0.07-0.54, p = .001) compared to PPCOS. In the normal pregnant groups, the prevalence of PIH was lower in Chilean women compared to Argentinian women (OR, 0.24, 95% CI: 0.10-0.62, p = .001). Similar to the pattern observed in the normal populations, newborns from PPCOS had higher birth weight and length compared with the newborns of PPCOS (p = .006 and .014, respectively). In conclusion, differences in pregnancy complications and obstetric outcomes between Chilean and Argentinian pregnant women with PCOS could be determined by ethnic diversity together with environmental factors of both populations. Impact Statement What is already known on this subject: The reproductive and metabolic phenotypes of women with polycystic ovary syndrome vary between different populations, which could significantly influence the obstetric and neonatal outcomes in this syndrome. What the results of this study add: Pregnant women with PCOS from two Latin American countries (Chile and Argentina) exhibit differences in the prevalence of gestational diabetes and pregnancy-induced hypertension, and in the birth weight of their newborns. What the implications are of these findings for clinical practice and/or further research: Ethnic diversity together with environmental factors are fundamental elements that must be considered in the management of pregnant women with PCOS.
对80名智利多囊卵巢综合征（PPCOS）孕妇和70名阿根廷多囊卵巢综合征（PPCOS）孕妇的妊娠并发症和产科结局进行了比较。同时也比较了来自相同产前护理单位的智利和阿根廷正常孕妇的参照组。与正常孕妇相比，多囊卵巢综合征孕妇妊娠期糖尿病（GDM）的患病率更高（OR，2.28，95%CI：1.08 - 4.77，p = 0.030），而妊娠高血压（PIH）的患病率更低（OR，0.20，95%CI：0.07 - 0.54，p = 0.001）。在正常孕妇组中，智利女性的妊娠高血压患病率低于阿根廷女性（OR，0.24，95%CI：0.10 - 0.62，p = 0.001）。与在正常人群中观察到的模式相似，多囊卵巢综合征孕妇的新生儿出生体重和身长高于正常孕妇的新生儿（分别为p = 0.006和0.014）。总之，智利和阿根廷多囊卵巢综合征孕妇在妊娠并发症和产科结局上的差异可能由种族多样性以及两国人群的环境因素共同决定。影响声明关于该主题已知的信息：多囊卵巢综合征女性的生殖和代谢表型在不同人群中存在差异，这可能会显著影响该综合征的产科和新生儿结局。本研究结果补充了什么：来自两个拉丁美洲国家（智利和阿根廷）的多囊卵巢综合征孕妇在妊娠期糖尿病和妊娠高血压的患病率以及新生儿出生体重方面存在差异。这些发现对临床实践和/或进一步研究有何意义：种族多样性以及环境因素是多囊卵巢综合征孕妇管理中必须考虑的基本要素。
