Department of Prenatal Diagnosis Center, First Affiliated Hospital of Guangxi Medical University, Nanning, China.
Reprod Biol Endocrinol. 2013 Jun 26;11:56. doi: 10.1186/1477-7827-11-56.
Polycystic ovary syndrome (PCOS) is a common endocrine disorder in women of childbearing age. The risk of pregnancy and neonatal complications in women with PCOS is debatable. In order to determine the risk of pregnancy and neonatal complications, evidence regarding these risks was examined.
Literature searches were performed in the electronic databases MEDLINE, EMBASE, and CENTRAL based on the established strategy and eligible tries were included according to inclusion and exclusion criteria. A systematic literature review looking at rates of gestational diabetes mellitus (GDM), pregnancy-induced hypertension (PIH), preeclampsia, premature delivery, neonatal birth weight, caesarean section and admission to a neonatal intensive care unit (NICU) was conducted in women with PCOS. Pregnancy outcomes between women with PCOS versus controls were included. Sensitivity analyses were performed to determine the reliability of the available evidence and to validate the results. The study was performed with the approval of the ethics committee of the First Affiliated Hospital of Guangxi Medical University.
A total of 27studies, involving 4982 women with PCOS and 119692 controls were eligible for the meta-analysis. Women with PCOS demonstrated a significantly higher risk of developing GDM (OR3.43; 95% CI: 2.49-4.74), PIH (OR3.43; 95% CI: 2.49-4.74), preeclampsia (OR2.17; 95% CI: 1.91-2.46), preterm birth (OR1.93; 95%CI: 1.45-2.57), caesarean section (OR 1.74; 95% CI: 1.38-2.11) compared to controls. Their babies had a marginally significant lower birth weight (WMD -0.11g; 95%CI: -0.19 - -0.03), and higher risk of admission to NICU (OR 2.32; 95% CI: 1.40-3.85) compared to controls.
Women with PCOS have increased risk of adverse pregnancy and neonatal complications. It is necessary to establish guidelines for supervision during pregnancy and parturition to prevent these complications.
多囊卵巢综合征（PCOS）是育龄妇女常见的内分泌疾病。患有 PCOS 的妇女的妊娠和新生儿并发症风险存在争议。为了确定妊娠和新生儿并发症的风险，对这些风险的证据进行了检查。
根据既定策略，在电子数据库 MEDLINE、EMBASE 和 CENTRAL 中进行文献检索，并根据纳入和排除标准纳入合格的试验。对患有 PCOS 的妇女的妊娠糖尿病（GDM）、妊娠高血压（PIH）、子痫前期、早产、新生儿出生体重、剖宫产和新生儿重症监护病房（NICU）入院率进行系统的文献复习。包括患有 PCOS 的妇女与对照组的妊娠结局。进行敏感性分析以确定可用证据的可靠性并验证结果。该研究得到广西医科大学第一附属医院伦理委员会的批准。
共有 27 项研究，涉及 4982 名患有 PCOS 的妇女和 119692 名对照者，符合荟萃分析的条件。患有 PCOS 的妇女发生 GDM（OR3.43；95%CI：2.49-4.74）、PIH（OR3.43；95%CI：2.49-4.74）、子痫前期（OR2.17；95%CI：1.91-2.46）、早产（OR1.93；95%CI：1.45-2.57）、剖宫产（OR1.74；95%CI：1.38-2.11）的风险显著高于对照组。她们的婴儿出生体重略低（WMD-0.11g；95%CI：-0.19-0.03），NICU 入院风险更高（OR2.32；95%CI：1.40-3.85），与对照组相比。
患有 PCOS 的妇女有发生不良妊娠和新生儿并发症的风险增加。有必要制定妊娠和分娩期间的监护指南，以预防这些并发症。
