Pharmacy Practice and Administrative Sciences, College of Pharmacy, University of New Mexico, Albuquerque, New Mexico, USA.
Department of Pediatrics, University of New Mexico, Albuquerque, New Mexico, USA.
Pediatr Res. 2018 Sep;84(3):362-370. doi: 10.1038/pr.2018.26. Epub 2018 May 16.
Earlier identification of children with prenatal alcohol exposure (PAE) remains a challenge. The objective of this study was to identify neurobehavioral (NB) outcomes associated with PAE in infants.
This manuscript evaluates NB outcomes at 6.33±1.12 months of age in 93 infants (39 PAE and 54 No-PAE) recruited prospectively into the ENRICH cohort. PAE was assessed by prospective repeated TLFB interviews and a panel of ethanol biomarkers. NB outcomes were evaluated by the Bayley Scales of Infant Development (BSID-III), Parenting Stress Index (PSI), Infant Behavior Questionnaire (IBQ-R), and Infant Sensory Profile (ISP).
Mean maternal age at enrollment was 28.18±5.75, and 64.52% were Hispanic/Latina. Across three TLFB calendars, absolute alcohol per day in the PAE group was 0.44±0.72, corresponding to low-moderate alcohol consumption. While no association was observed between PAE and BSID-III (P's>0.05), PAE was associated with higher scores on the PSI difficult child scale ([Formula: see text]=13.9; P=0.015), total stress ([Formula: see text]=13.9; P=0.010), and IBQ negative affect ([Formula: see text]=8.60; P=0.008) measures after adjustment for covariates.
Caregiver-reported assessments may provide a currently unrecognized opportunity to identify behavioral deficits, point to early interventions, and should be included in clinical assessments of infants at-risk for fetal alcohol spectrum disorder.
早期识别有产前酒精暴露（PAE）的儿童仍然是一个挑战。本研究的目的是确定与婴儿 PAE 相关的神经行为（NB）结果。
本手稿评估了前瞻性纳入 ENRICH 队列的 93 名婴儿（39 名 PAE 和 54 名非 PAE）在 6.33±1.12 月龄时的 NB 结果。PAE 通过前瞻性重复 TLFB 访谈和一组乙醇生物标志物进行评估。NB 结果通过贝利婴幼儿发展量表（BSID-III）、父母压力指数（PSI）、婴儿行为问卷（IBQ-R）和婴儿感觉量表（ISP）进行评估。
入组时母亲的平均年龄为 28.18±5.75，64.52%为西班牙裔/拉丁裔。在三个 TLFB 日历中，PAE 组每天的绝对酒精量为 0.44±0.72，对应于低-中度饮酒。虽然在 PAE 与 BSID-III 之间未观察到相关性（P>0.05），但 PAE 与 PSI 困难儿童量表的较高评分相关（[Formula: see text]=13.9；P=0.015）、总压力（[Formula: see text]=13.9；P=0.010）和 IBQ 负性情绪（[Formula: see text]=8.60；P=0.008），在调整协变量后。
照顾者报告的评估可能提供了一个当前未被认识到的机会，可以识别行为缺陷，指出早期干预措施，并且应该包括在对有胎儿酒精谱系障碍风险的婴儿进行的临床评估中。
