Giro Gabriela, Sakakura Celso Eduardo, Gonçalves Daniela, Pereira Rosa M R, Marcantonio Elcio, Orrico Silvana R P
Department of Oral Diagnosis and Surgery, School of Dentistry of Araraquara, State University of São Paulo, Araraquara, SP, Brazil.
Department of Rheumatology, School of Medicine, University of São Paulo, São Paulo, SP, Brazil.
J Periodontol. 2007 Jul;78(7):1316-1321. doi: 10.1902/jop.2007.060390.
This study investigated the influence of estrogen deficiency and its treatment with estrogen and alendronate on the removal torque of osseointegrated titanium implants.
Fifty-eight female Wistar rats received a titanium implant in the tibia metaphysis. After 60 days, which was needed for implant osseointegration, the animals were randomly divided into five groups: control (CTLE; N = 10), sham surgery (SHAM; N = 12), ovariectomy (OVX; N = 12), ovariectomy followed by hormone replacement (EST; N = 12), and ovariectomy followed by treatment with alendronate (ALE; N = 12). The CTLE group was sacrificed to confirm osseointegration, whereas the remaining groups were submitted to sham surgery or ovariectomy according to their designations. After 90 days, these animals were also sacrificed. Densitometry of femur and lumbar vertebrae was performed by dual-energy x-ray absorptiometry (DXA) to confirm systemic impairment of the animals. All implants were subjected to removal torque.
Densitometric analysis of the femur and lumbar vertebrae confirmed a systemic impairment of the animals, disclosing lower values of bone mineral density for OVX. Analysis of the removal torque of the implants showed statistically lower values (P <0.05) for the OVX group in relation to the other groups. However, the group treated with alendronate (ALE group) presented significantly higher torque values compared to the others.
According to this study, estrogen deficiency was observed to have a negative influence on the removal torque of osseointegrated implants, whereas treatment with alendronate increased the torque needed to remove the implants.
本研究调查了雌激素缺乏及其雌激素和阿仑膦酸盐治疗对骨整合钛种植体去除扭矩的影响。
58只雌性Wistar大鼠在胫骨近端干骺端植入钛种植体。在种植体骨整合所需的60天后，将动物随机分为五组：对照组（CTLE；n = 10）、假手术组（SHAM；n = 12）、卵巢切除组（OVX；n = 12）、卵巢切除后激素替代组（EST；n = 12）和卵巢切除后阿仑膦酸盐治疗组（ALE；n = 12）。处死CTLE组以确认骨整合情况，而其余组根据其分组进行假手术或卵巢切除术。90天后，这些动物也被处死。通过双能X线吸收法（DXA）对股骨和腰椎进行骨密度测定，以确认动物的全身性功能损害。所有种植体均进行去除扭矩测试。
股骨和腰椎的骨密度分析证实了动物的全身性功能损害，显示OVX组的骨矿物质密度值较低。种植体去除扭矩分析显示，与其他组相比，OVX组的数值在统计学上较低（P <0.05）。然而，阿仑膦酸盐治疗组（ALE组）的扭矩值明显高于其他组。
根据本研究，观察到雌激素缺乏对骨整合种植体的去除扭矩有负面影响，而阿仑膦酸盐治疗增加了去除种植体所需的扭矩。
