Department of Polymeric Materials, School of Materials Science and Engineering , Tongji University , 4800 Caoan Road , Shanghai 201804 , China.
Department of Orthopedics, Shanghai Tenth People's Hospital , Tongji University School of Medicine , Shanghai 200072 , China.
Biomacromolecules. 2018 Jun 11;19(6):1701-1720. doi: 10.1021/acs.biomac.8b00208. Epub 2018 Mar 27.
Antimicrobial peptides (AMPs) have been attracting much attention due to their excellent antimicrobial efficiency and low rate in driving antimicrobial resistance (AMR), which has been increasing globally to alarming levels. Conjugation of AMPs into functional polymers not only preserves excellent antimicrobial activities but reduces the toxicity and offers more functionalities, which brings new insight toward developing multifunctional biomedical materials such as hydrogels, polymer vesicles, polymer micelles, and so forth. These nanomaterials have been exhibiting excellent antimicrobial activity against a broad spectrum of bacteria including multidrug-resistant (MDR) ones, high selectivity, and low cytotoxicity, suggesting promising potentials in wound dressing, implant coating, antibiofilm, tissue engineering, and so forth. This Perspective seeks to highlight the state-of-the-art strategy for the synthesis, self-assembly, and biomedical applications of AMP-polymer conjugates and explore the promising directions for future research ranging from synthetic strategies, multistage and stimuli-responsive antibacterial activities, antifungi applications, and potentials in elimination of inflammation during medical treatment. It also will provide perspectives on how to stem the remaining challenges and unresolved problems in combating bacteria, including MDR ones.
抗菌肽（AMPs）由于其优异的抗菌效率和低抗菌耐药性（AMR）发生率而备受关注，全球范围内的 AMR 发生率正以惊人的速度上升。将 AMP 与功能聚合物偶联不仅保留了优异的抗菌活性，还降低了毒性并提供了更多功能，为开发多功能生物医学材料（如水凝胶、聚合物囊泡、聚合物胶束等）带来了新的思路。这些纳米材料对包括多药耐药（MDR）菌在内的广谱细菌表现出优异的抗菌活性、高选择性和低细胞毒性，在伤口敷料、植入物涂层、抗生物膜、组织工程等方面具有广阔的应用前景。本综述旨在强调 AMP-聚合物缀合物的合成、自组装和生物医学应用的最新策略，并探讨未来研究的有前途的方向，包括合成策略、多阶段和刺激响应抗菌活性、抗真菌应用以及在医疗过程中消除炎症的潜力。还将提供如何应对抗菌方面（包括 MDR 菌）剩余挑战和未解决问题的观点。
