Moazed D, Noller H F
Nature. 1987;327(6121):389-94. doi: 10.1038/327389a0.
Chemical footprinting shows that several classes of antibiotics (streptomycin, tetracycline, spectinomycin, edeine, hygromycin and the neomycins) protect concise sets of highly conserved nucleotides in 16S ribosomal RNA when bound to ribosomes. These findings have strong implications for the mechanism of action of these antibiotics and for the assignment of functions to specific structural features of 16S rRNA.
化学足迹法表明，几类抗生素（链霉素、四环素、壮观霉素、伊短菌素、潮霉素和新霉素）与核糖体结合时，会保护16S核糖体RNA中一组高度保守的核苷酸。这些发现对于这些抗生素的作用机制以及16S rRNA特定结构特征的功能分配具有重要意义。
