Ford M J, Bickle Q D, Taylor M G
Parasitology. 1987 Apr;94 ( Pt 2):313-26. doi: 10.1017/s003118200005397x.
Immunity to Schistosoma mansoni was investigated in congenitally athymic (Nu/Nu) rats, irradiated rats and in mast cell-depleted rats. Nu/Nu rats failed to develop significant resistance following vaccination with irradiated cercariae, although Nu/Nu recipients of serum from vaccinated Fischer rats (VRS) manifested resistance comparable to heterozygous controls, suggesting that T-cells were required in the induction of resistance but were not involved in the efferent arm of antibody-dependent elimination. Radiosensitive cells (including eosinophils, basophils, neutrophils, lymphocytes and mast cells) were apparently not essential for the antibody-dependent elimination of lung or post-lung stages since irradiated (700-750 rad.) recipients of VRS manifested comparable degrees of resistance to unirradiated controls in spite of a greater than 85% reduction in total blood leucocyte counts after irradiation. Depletion of 99% of tissue mast cells by treatment of rats with Compound 48/80 had no significant effect on the attrition of a challenge infection in rats rendered immune by vaccination with irradiated cercariae or by transfer of VRS. However, there was a significant increase in worm recovery in unimmunized and mast cell-depleted or irradiated rats, indicating that mast cells and perhaps other radio-isotope sensitive cells may be involved in innate resistance.
在先天性无胸腺（Nu/Nu）大鼠、受辐照大鼠和肥大细胞耗竭的大鼠中研究了对曼氏血吸虫的免疫力。Nu/Nu大鼠在用辐照尾蚴接种后未能产生显著抗性，尽管接种过的费希尔大鼠血清（VRS）的Nu/Nu受体表现出与杂合对照相当的抗性，这表明T细胞在抗性诱导中是必需的，但不参与抗体依赖性消除的传出环节。放射敏感细胞（包括嗜酸性粒细胞、嗜碱性粒细胞、中性粒细胞、淋巴细胞和肥大细胞）显然对于抗体依赖性消除肺部或肺部后阶段并非必不可少，因为VRS的辐照（700 - 750拉德）受体尽管辐照后全血白细胞计数减少超过85%，但仍表现出与未辐照对照相当的抗性程度。用化合物48/80处理大鼠使99%的组织肥大细胞耗竭，对通过用辐照尾蚴接种或转移VRS而获得免疫的大鼠中攻击感染的消耗没有显著影响。然而，在未免疫且肥大细胞耗竭或受辐照的大鼠中虫体回收率显著增加，表明肥大细胞以及可能其他对放射性同位素敏感的细胞可能参与天然抗性。
