Ford M J, Dissous C, Pierce R J, Taylor M G, Bickle Q D, Capron A
Parasitology. 1987 Jun;94 ( Pt 3):509-22. doi: 10.1017/s0031182000055852.
The role of different antibody isotypes in the transfer of protection with serum from rats vaccinated with irradiated cercariae were investigated by immunoadsorption of IgG, IgG2a and IgG2c, and by heating at 56 degrees C to remove IgE. Only depletion of IgG2a reduced the levels of vaccine-induced immunity transferred, whereas immunity transferred by infection serum was reduced by both IgG2a and IgE depletion. It was also shown that exposure to irradiated parasites did not lead to either specific or non-specific induction of an IgE response. The successful passive-transfer experiments using serum from non-resistant 25 week-infected rats into recipient animals demonstrated that the waning of resistance observed in 25 week-infected rats was not due to a failure of the humoral response to protective antigens.
通过对IgG、IgG2a和IgG2c进行免疫吸附，以及在56℃加热以去除IgE，研究了不同抗体同种型在用辐照尾蚴免疫的大鼠血清中传递保护性免疫方面的作用。仅去除IgG2a会降低疫苗诱导的传递免疫水平，而感染血清传递的免疫在去除IgG2a和IgE后均降低。还表明，暴露于辐照寄生虫不会导致IgE反应的特异性或非特异性诱导。使用来自未产生抗性的感染25周大鼠的血清对受体动物进行的成功被动转移实验表明，在感染25周的大鼠中观察到的抗性减弱并非由于对保护性抗原的体液反应失败所致。
