Pochmann Daniela, Peccin Pâmela Krause, da Silva Ivy Reichert Vital, Dorneles Gilson Pires, Peres Alessandra, Nique Simone, Striebel Vera, Elsner Viviane Rostirola
Programa de Pós Graduação em Biociências e Reabilitação do Centro Universitário Metodista-IPA, Porto Alegre, RS, Brazil.
Curso de Fisioterapia do Centro Universitário Metodista-IPA, Porto Alegre, RS, Brazil.
Neurosci Lett. 2018 May 1;674:30-35. doi: 10.1016/j.neulet.2018.03.021. Epub 2018 Mar 11.
The study aimed to compare the basal plasma levels of inflammatory markers (MCP-1, IL-1ra and IL-1β) in Parkinson Disease group (PDG) with control healthy subjects (control group, CG), as well to investigate the acute and chronic effects of an aquatic physiotherapy program on these biomarkers in PDG. Firstly, a rest blood sampling was taken from antecubital vein of the PD and CG. After, the PD individuals were submitted to a supervisioned aquatic physiotherapy program during 1 month, twice a week (60 min/session). In order to evaluate the acute and chronic effects of the intervention on the biomarkers, blood samples were in 4 times: before the exercise program (pre), immediately after the first session, 48 h after the exercise session and 1 month after the intervention. It was observed higher levels of the pro-inflammatory cytokines IL-1β and MCP-1 and reduced levels IL-1ra in PDG compared to the CG. Regarding the intervention effects in PDG, a remarkable reduction on IL-1β and MCP-1 levels at 48 h when compared to the basal were found. Furthermore, after 1 month, it was observed diminished levels of MCP-1 in combination to an increase on IL-1ra. Our data support the idea that an inflammatory status is linked to PD and that MCP-1 and IL-1ra could be taken as promising biomarkers in this condition. We also demonstrated that an aquatic physiotherapy program may offer a potential intervention able to attenuate immune responses in PD individuals in a short and long-term perspective.
该研究旨在比较帕金森病组（PDG）与健康对照组（CG）中炎症标志物（MCP-1、IL-1ra和IL-1β）的基础血浆水平，并研究水上物理治疗方案对PDG中这些生物标志物的急性和慢性影响。首先，从PD组和CG组的肘前静脉采集静息血样。之后，PD组个体接受为期1个月的有监督的水上物理治疗方案，每周两次（每次60分钟）。为了评估干预对生物标志物的急性和慢性影响，在运动方案前（pre）、第一次治疗后立即、运动治疗后48小时以及干预后1个月这4个时间点采集血样。结果观察到，与CG组相比，PDG组中促炎细胞因子IL-1β和MCP-1水平较高，而IL-1ra水平较低。关于对PDG组的干预效果，与基础水平相比，在48小时时IL-1β和MCP-1水平显著降低。此外，1个月后，观察到MCP-1水平降低，同时IL-1ra水平升高。我们的数据支持炎症状态与PD相关的观点，并且在这种情况下MCP-1和IL-1ra可作为有前景的生物标志物。我们还证明，从短期和长期来看，水上物理治疗方案可能提供一种潜在的干预措施，能够减轻PD个体的免疫反应。
