Dani Caroline, Proença Isabel Teixeira, Marinho Jessica, Peccin Pâmela, da Silva Ivy Reichert Vital, Nique Simone, Striebel Vera, Pochmann Daniela, Elsner Viviane Rostirola
Programa de Pós Graduação em Biociências e Reabilitação do Centro Universitário Metodista-IPA, Porto Alegre; Programa de Pós Graduação em Farmacologia e Terapêutica, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil.
Programa de Pós Graduação em Biociências e Reabilitação do Centro Universitário Metodista-IPA, Porto Alegre, RS, Brazil.
Neural Regen Res. 2020 Nov;15(11):2067-2072. doi: 10.4103/1673-5374.276337.
Parkinson's disease is a neurodegenerative disease. Oxidative stress, i.e., the imbalance between the generation of reactive oxygen species and the antioxidant defense capacity of the body, plays an important role in the pathogenesis of this disease. Physical exercise can regulate oxidative stress. The purpose of this study was to analyze the short- and long-term effects of an aquatic exercise program on oxidative stress levels in patients with Parkinson's disease. The aquatic exercise program was carried out during 1 month with two sessions per week (1 hour/session). Blood samples were collected at four different time points: pre-intervention, immediately, 48 hours, and 30 days after the first session of aquatic exercise program. Our results revealed that water-based programs modulated antioxidant enzyme activity, increased superoxide dismutase activity, reduced catalase activity, and increased the ratio of superoxide dismutase activity to catalase activity in patients with Parkinson's disease. Compared with pre-intervention and 48 hours after the first session of aquatic exercise program, superoxide dismutase activity was higher and catalase activity was lower immediately and 30 days after the first session. Our results demonstrated that aquatic exercise program could modulate oxidative stress, mainly by the effect of antioxidant enzyme activity. These results could better help understand the target of oxidative stress in Parkinson's disease. This study was approved by the Ethics Committee of Centro Universitário Metodista IPA (approval No. 1.373.911) on August 9, 2019 and registered with REBEC (registration number: RBR-6NJ4MK).
帕金森病是一种神经退行性疾病。氧化应激，即活性氧的产生与机体抗氧化防御能力之间的失衡，在该疾病的发病机制中起重要作用。体育锻炼可以调节氧化应激。本研究的目的是分析水上运动计划对帕金森病患者氧化应激水平的短期和长期影响。水上运动计划为期1个月，每周进行两次（每次1小时）。在四个不同时间点采集血样：干预前、第一次水上运动计划课程后即刻、48小时和30天。我们的结果显示，水上运动计划可调节帕金森病患者抗氧化酶活性，增加超氧化物歧化酶活性，降低过氧化氢酶活性，并提高超氧化物歧化酶活性与过氧化氢酶活性的比值。与干预前及第一次水上运动计划课程后48小时相比，第一次课程后即刻和30天时超氧化物歧化酶活性较高，过氧化氢酶活性较低。我们的结果表明，水上运动计划可调节氧化应激，主要是通过抗氧化酶活性的作用。这些结果有助于更好地理解帕金森病氧化应激的靶点。本研究于2019年8月9日获得Centro Universitário Metodista IPA伦理委员会批准（批准号：1.373.911），并在REBEC注册（注册号：RBR-6NJ4MK）。
